Biomedical Research

KEY FINDING: Hydrogen sulfide (H2S) has anti-inflammatory and anti-apoptotic effects and can protect the spinal cord. It reduces oxidative stress and promotes axon growth.

KEY FINDING: HADA/HRR hydrogels can reverse the formation of fibrotic scar after SCI, transforming it into a supportive substrate for regenerating axons.

KEY FINDING: Dysfunctional pathological microenvironment in SCI comprises excessive inflammation, deposition of inhibitory molecules, neurotrophic factor deprivation, glial scar formation, and imbalance of vascular function.

KEY FINDING: The decellularization process effectively removed cellular components from spinal cords and sciatic nerves while preserving the ECM structure.

KEY FINDING: GEES effectively stimulates macrophages to secrete anti-inflammatory cytokines, promoting a favorable microenvironment.

KEY FINDING: NS@COP restores the responsiveness of pro-inflammatory macrophages to CGRP by upregulating RAMP1, promoting an anti-inflammatory M2 phenotype.

KEY FINDING: Adding SDS and SAPs to electrospun PVDF scaffolds results in thinner, more uniform fibers, enhancing the electroactive phases.

KEY FINDING: PPT NMs effectively mitigated LPS-stimulated cell apoptosis, in a dose-dependent manner, suggesting an anti-apoptotic effect.

KEY FINDING: PEs from L. barbarum L. possess anti-inflammatory and neuronal differentiation promotion capabilities, showing enhanced neural differentiation compared to exosomes from ectomesenchymal stem cells (EMSCs).

KEY FINDING: The LaD/Me/Te-h hydrogel demonstrated superior radical scavenging abilities compared to La-h and LaD/Me-h groups, attributed to antioxidant polyphenol groups and Te nanoparticles.