Latest Research Summaries

KEY FINDING: DPSCs are involved in nerve repair in SCI through various pathways, such as anti-inflammatory effects, promotion of axonal regeneration, reduction of apoptosis, and immunomodulation.

KEY FINDING: Intraperitoneal injections of cycloastragenol (CAG) significantly promoted the growth of in vitro-cultured dorsal root ganglion (DRG) axons.

KEY FINDING: Ectopic expression of allogeneic MHC in the recipient thymus leads to stable expression in TECs and DCs.

KEY FINDING: Screening under-estimated traumatic brain injury incidence when approaches relied on inconsistently collected traumatic brain injury indicators, especially for mild traumatic brain injury.

KEY FINDING: Early surgical resection of heterotopic ossification (HO) in the knee, performed just 4 months after symptom onset, resulted in a good clinical and functional outcome for a young woman.

KEY FINDING: hscNPCs remodeled the injury microenvironment shortly after transplantation by reducing inflammation and enhancing angiogenesis, leading to increased endogenous neuronal regeneration.

KEY FINDING: SCI induces increased AEA content and hyperactivity in nociceptors, with the timing of SCI-induced hyperexcitability paralleling an increase in AEA content.

KEY FINDING: GBMs can be modified to enhance their biocompatibility and effectiveness in stimulating nerve regeneration.

KEY FINDING: The GDNF-PLNG/siMIF scaffold promotes neuron regeneration by upregulation of neuron cytokine production and inhibits inflammation through the downregulation immune pathway.

KEY FINDING: The study identified severity-specific biomarker genes that allow precise classification of transcriptomic profiles, indicating potential for injury prognosis prediction.