Browse our collection of 12,052 research summaries, all carefully curated and simplified for the spinal cord injury community.
Showing 291-300 of 12,052 results
Curr Top Dev Biol, 2025 • January 1, 2025
This article reviews the role of ATRA in early mouse embryogenesis, highlighting its functions in hindbrain/spinal cord patterning, Fgf8 repression for somitogenesis and heart morphogenesis, and optic...
KEY FINDING: Early-generated ATRA performs three essential functions: (1) activation of genes that control hindbrain and spinal cord patterning; (2) repression of Fgf8 in the heart field and caudal progenitors; and (3) actions that stimulate invagination of the optic vesicle to form the optic cup.
European Journal of Pain, 2025 • January 1, 2025
This translational study examined the interaction between descending inhibitory controls and spinal amplification in pain modulation, using parallel human and rat models. The study found that spinal a...
KEY FINDING: In humans, concurrent application of a noxious conditioning stimulus did not affect pain ratings to a single pinprick stimulus, repetitive stimulation or the wind-up ratio.
ASN NEURO, 2025 • January 1, 2025
Functional recovery following spinal cord injury will require the regeneration and repair of damaged neuronal pathways. Neurons in the brain and spinal cord are a diverse group of cells with many popu...
KEY FINDING: The neuronal response to injury is variable, based on multiple factors, including the location of the injury with respect to the neuronal cell bodies and the affected neuronal populations.
Journal of Translational Medicine, 2025 • January 1, 2025
This study investigates the therapeutic potential of amantadine in modulating macrophage phenotypes to enhance neural repair following spinal cord injury (SCI). The research identifies three distinct ...
KEY FINDING: Three distinct macrophage subtypes were identified in the injured spinal cord: border-associated macrophages (BAMs), inflammatory macrophages (IMs), and chemotaxis-inducing macrophages (CIMs).
Journal of Rehabilitation and Assistive Technologies Engineering, 2025 • January 1, 2025
This pilot study investigated the feasibility of using an end-effector robot-assisted gait trainer (E-RAGT) to help individuals with spinal cord injury or stroke reach recommended levels of exercise i...
KEY FINDING: Every participant was able to reach moderate-to-vigorous exercise intensity on the E-RAGT.
Nature Communications, 2025 • January 1, 2025
This document is an author correction for a previously published article in Nature Communications. The correction pertains to the affiliation details of one of the authors, Jun Zhang. The corrected af...
KEY FINDING: This is a correction to the author's affiliation; there are no key findings reported here.
Journal of Cellular Physiology, 2025 • January 1, 2025
This review highlights the significance of pericytes in spinal cord injury (SCI) repair, focusing on their role in vascular regeneration and interaction within the neurovascular unit (NVU). Pericytes ...
KEY FINDING: Pericytes are essential for maintaining the integrity of the spinal cord vasculature after SCI by providing neuroprotection, maintaining stem cell pluripotency, and promoting angiogenesis and vessel maturation.
eNeuro, 2025 • January 1, 2025
This study demonstrates that norepinephrine axons in the adult mouse brain are capable of regrowth following injury induced by the neurotoxin DSP4, challenging the widely held belief that axons in the...
KEY FINDING: Norepinephrine axons in the adult mouse brain can regrow following injury induced by DSP4.
The Journal of Neuroscience, 2025 • January 1, 2025
This study investigates the role of nonresolving neuroinflammation in regulating axon regeneration in chronic spinal cord injury (SCI). The researchers used PLX-5622 to deplete microglia and macrophag...
KEY FINDING: Macrophages and microglia repopulate the chronically injured spinal cord after depletion, indicating a homeostatic mechanism maintaining their presence.
J Eur Acad Dermatol Venereol, 2025 • January 1, 2025
The study investigated plasma levels of CGRP in individuals with rosacea and healthy controls to understand CGRP's role in rosacea pathogenesis. The results showed elevated plasma levels of CGRP in in...
KEY FINDING: Plasma levels of CGRP were significantly higher in individuals with rosacea compared to healthy controls after adjusting for age and sex.