Browse our collection of 12,052 research summaries, all carefully curated and simplified for the spinal cord injury community.
Showing 271-280 of 12,052 results
Materials Today Bio, 2025 • January 7, 2025
The study developed an injectable hydrogel (OPDL gel) for treating spinal cord injuries and providing wound care. The hydrogel encapsulates dexamethasone (Dex) and responds to reactive oxygen species ...
KEY FINDING: The OPDL gel demonstrated excellent injectability and self-healing properties, allowing its precise application at the site of spinal cord injury by using a syringe for effective care delivery.
Communications Biology, 2025 • January 7, 2025
This study provides a spatiotemporal atlas of young and aged spinal cord tissues using spatial transcriptomics, revealing changes in gene expression between grey and white matter regions. Integration ...
KEY FINDING: Bulk RNA sequencing identified 526 upregulated genes and 300 downregulated genes in senescent spinal cords compared to young spinal cords, with pathways related to phagosome function, neuroinflammation, ferroptosis, and necroptosis being enriched.
Journal of NeuroEngineering and Rehabilitation, 2025 • January 7, 2025
This study evaluated the effectiveness of transcutaneous spinal cord stimulation (tSCS) combined with robotic-assisted gait training (RAGT) on lower limb muscle strength and walking function in incomp...
KEY FINDING: The tSCS group showed greater effects than the sham-tSCS group for LEMS (3.4 points; p = 0.033), 10MWT (37.5 s; p = 0.030), TUG (47.7 s; p = 0.009), and WISCI-II (3.4 points; p = 0.023) at the 1-month follow-up compared to baseline.
Front. Neurosci., 2025 • January 7, 2025
Mitochondria, supplying most ATP through oxidative phosphorylation, produce mtROS byproducts that can act as molecular signals or cause cell death. Maintaining a healthy mitochondrial state involves m...
KEY FINDING: Mitochondrial protein acetylation, particularly through enzymes like GCN5L1 and Sirt3, plays a significant role in neuronal activity and the pathophysiology of cerebral injury. Sirt3, for example, regulates processes such as mPTP opening, mitochondrial dynamics, and mitophagy, protecting mitochondrial function and preventing neuronal death in ischemic stroke.
Scientific Data, 2025 • January 6, 2025
This study presents a comprehensive chromatin accessibility dataset of the rat nervous system using single-cell ATAC-seq, profiling 174,593 high-quality nuclei from 16 adult rat brain regions. The res...
KEY FINDING: Identified cell subtypes of both neuronal and non-neuronal cells with highly specific distributions in 16 adult rat brain regions.
Journal of Molecular Histology, 2025 • January 6, 2025
This study evaluated the therapeutic effect of combined ceftriaxone and ADMSCs in a rodent model of acute spinal infection (ASI). The results showed that the combined therapy was superior to ceftriaxo...
KEY FINDING: The combination of ceftriaxone and ADMSCs resulted in significantly lower levels of TNF-α and IL-6 in both circulatory and spinal cord fluid compared to ceftriaxone or ADMSCs alone, indicating a stronger anti-inflammatory effect.
Journal of Orthopaedic Surgery and Research, 2025 • January 6, 2025
This systematic review consolidates research on dysphonia following ACDF, revealing inconsistencies in prevalence, clinical presentation, and measurement. The variability in reported dysphonia inciden...
KEY FINDING: The incidence of voice complications after ACDF varied widely, from 0.3 to 27%, likely due to differing measurement methods.
Front. Rehabil. Sci., 2025 • January 6, 2025
This case report investigated the effects of focal muscle vibration (fMV) combined with neurocognitive exercises on a 46-year-old patient with spastic paraparesis secondary to spinal ependymoma remova...
KEY FINDING: The patient showed an overall improvement in assessment scales after treatment, indicating reduced spasticity and pain.
Frontiers in Rehabilitation Sciences, 2025 • January 6, 2025
This Research Topic showcases current practices and implementation of co-design in rehabilitation research and service delivery, and to encourage further reflection on how the field can move forward i...
KEY FINDING: Communication, consistency and connection were key factors that could enhance engagement in pediatric telerehabilitation and reduce barriers to care.
International Medical Case Reports Journal, 2025 • January 4, 2025
This case report describes a 68-year-old male diagnosed with TTR-FAP with an uncommon presentation of spinal cord damage. The patient's symptoms included progressive limb weakness and numbness, autono...
KEY FINDING: The patient presented with a rare manifestation of TTR-FAP, specifically spinal cord damage, which is not commonly associated with the c.148G>A (p.Val50Met) mutation.