Browse our collection of 12,052 research summaries, all carefully curated and simplified for the spinal cord injury community.
Showing 261-270 of 12,052 results
Scientific Reports, 2025 • January 8, 2025
This study investigates the role of SIX1 in microglia polarization following spinal cord injury (SCI) in mice. The researchers found that SIX1 expression increases in microglia after SCI and promotes ...
KEY FINDING: SIX1 expression increases in microglia following SCI in mice and is positively correlated with the M1 microglia marker iNOS and negatively correlated with the M2 microglia marker Arg1.
Scientific Reports, 2025 • January 8, 2025
This study investigates the role of cuproptosis in spinal cord injury (SCI) using bioinformatics analysis of RNA sequencing data from SCI samples. It identifies hub genes, including Cd48 and Mpeg1, an...
KEY FINDING: Two hub genes, Cd48 and Mpeg1, were identified and exhibited a strong positive correlation (R = 0.92) and shared similar pathways, suggesting their importance in SCI.
Journal of Tissue Engineering, 2025 • January 8, 2025
This study explores the potential of umbilical cord mesenchymal stem cells (UCMSCs) in treating rotator cuff tendon injuries, which often lead to shoulder pain and dysfunction. The research identifies...
KEY FINDING: CTGF was found to be the most effective growth factor for inducing the differentiation of UCMSCs into tendon cells, leading to changes in cell morphology and increased expression of tendon-specific proteins.
Journal of Orthopaedic Translation, 2025 • January 8, 2025
This study investigates the role of ISRIB in promoting neural functional recovery following SCI and elucidates its underlying molecular mechanisms. The findings revealed that ISRIB suppressed apoptosi...
KEY FINDING: ISRIB suppresses neuron death and neuroinflammation following SCI.
Journal of Medical Case Reports, 2025 • January 8, 2025
This case report describes the successful insertion of a new intrathecal baclofen catheter in a patient with a fractured catheter, without removing the original fractured catheter. The new catheter wa...
KEY FINDING: The intrathecal baclofen catheter breakage was identified as the cause of the patient's worsening spasticity 13 years after the initial pump implantation.
Biomimetics, 2025 • January 8, 2025
This qualitative study explored the acceptability of overground wearable powered exoskeletons among people with spinal cord injuries (SCI) in rehabilitation settings. The study found that participants...
KEY FINDING: Participants were generally motivated and satisfied with using exoskeletons during rehabilitation, with many hoping it would help them walk again or improve their walking pattern.
Cells, 2025 • January 7, 2025
This study provides the first direct transcriptomic and functional comparison of syngeneic adult human NSPC populations, including bona fide spinal cord NSPCs and iPSC-derived NSPCs regionalized to th...
KEY FINDING: iPSC-Br NSPCs exhibit a closer resemblance to bona fide spinal cord NSPCs, characterized by enriched expression of neurogenesis, axon guidance, synaptic signaling, and voltage-gated calcium channel activity pathways.
Journal of Nanobiotechnology, 2025 • January 7, 2025
This study developed a Lightgel/NGF/CeMn NP-PEG composite material that promotes neuronal repair and regeneration, enhances the immune microenvironment post-SCI, and demonstrates remarkable therapeuti...
KEY FINDING: The Lightgel/NGF/CeMn NP-PEG composite effectively eliminates ROS, promoting M2 macrophage polarization. It also reduces pro-inflammatory cytokines, and supports neuronal regeneration in SCI rats.
Nanoscale Advances, 2025 • January 7, 2025
This study explores the use of pyrroloquinoline quinone (PQQ) loaded on coaxial nanofibers as an implantable drug-delivery system to combat oxidative stress following spinal cord injury (SCI) in rats. ...
KEY FINDING: The concentration of NO and the activity of iNOS were significantly increased in the SCI group but were significantly decreased following treatment with nanofibers/PQQ.
Frontiers in Neuroanatomy, 2025 • January 7, 2025
This review discusses the limitations of current neuropathic pain treatments and introduces a novel approach using capsaicin and RTX. Preclinical data suggests that applying these substances to uninju...
KEY FINDING: In an animal model of neuropathic pain, application of capsaicin or RTX to adjacent uninjured nerves completely alleviated and prevented mechanical and thermal hyperalgesia following L5 nerve injury.