Browse our collection of 12,052 research summaries, all carefully curated and simplified for the spinal cord injury community.
Showing 11,891-11,900 of 12,052 results
Glia, 2007 • May 1, 2007
This study examined the role of Myt1, a transcription factor, in oligodendrocyte regeneration and remyelination in both rodent and human CNS demyelinated lesions. The MHV model was used to induce spin...
KEY FINDING: The density of Myt1 expressing cells markedly increased in lesioned areas of spinal cord white matter in MHV-infected mice, peaking during early remyelination.
Neuron Glia Biol., 2007 • May 1, 2007
The study investigates the use of electrospun polydioxanone (PDS) matrices with aligned or random fibers to guide axonal regeneration after spinal cord injury. The directionality and growth dynamics o...
KEY FINDING: Electrospinning can produce matrices with aligned or randomly oriented fibers, confirmed by 2-D FFT analysis.
Br J Sports Med, 2007 • April 30, 2007
This study investigated the shoulder joint kinetics of elite wheelchair tennis players during flat and kick serves, comparing them to able-bodied players to assess injury risk and inform coaching prac...
KEY FINDING: Wheelchair players generate similar pre-impact absolute racquet velocities in both flat and kick serves, but with different horizontal and lateral components.
The Journal of Neuroscience, 2007 • April 11, 2007
This study identifies that the nonsteroidal anti-inflammatory drugs (NSAIDs) ibuprofen and indomethacin overcome neuronal growth inhibitions from CNS myelin and CSPGs via repressing the activity of in...
KEY FINDING: Ibuprofen and indomethacin reverse RhoA activation induced by CNS myelin, CSPGs, or spinal cord lesion.
PLoS Medicine, 2007 • April 10, 2007
The study investigates the potential of TREM2-transduced myeloid precursor cells to mediate nervous tissue debris clearance and facilitate recovery in an animal model of multiple sclerosis (EAE). Resu...
KEY FINDING: TREM2-transduced myeloid cells migrated to inflammatory lesions in the spinal cord of EAE mice.
Arch Phys Med Rehabil, 2007 • April 1, 2007
The study designed the 6-MAT, a submaximal arm ergometry test for individuals with SCI, and determined its test-retest reliability and concurrent validity. The 6-MAT demonstrated acceptable test-retes...
KEY FINDING: Test-retest reliability of steady state VO2 and heart rate (HR) during the 6-MAT were excellent; intraclass correlation coefficient (ICC)=0.81 [95% confidence interval (CI)=0.58–0.92], and 0.90 (95%CI=0.75–0.96), respectively.
J Comp Neurol, 2007 • April 1, 2007
This study investigates the expression patterns of netrin, Sema3, and Sema4 in the lamprey spinal cord during regeneration after transection. In control lampreys, netrin was expressed in neurons along...
KEY FINDING: Netrin expression was downregulated in neurons near the spinal cord transection site at 2 and 4 weeks post-injury, suggesting it may be involved in restricting axonal regeneration.
PNAS, 2007 • March 13, 2007
The study identifies pleiotrophin (PTN) as a neurotrophic factor upregulated in denervated distal nerve and muscle. Exogenous PTN enhances axonal regeneration and protects facial motor neurons from tr...
KEY FINDING: PTN mRNA is upregulated in denervated Schwann cells and muscle after axotomy, peaking at 7 days and returning to baseline by 3 months.
Brain Res., 2007 • March 9, 2007
Increases in extracellular GABA in the L3/L4 spinal cord occur in response to high frequency TENS, but not low frequency TENS. Blockade of GABAA in the spinal cord reduced the antihyperalgesia produce...
KEY FINDING: High frequency TENS increases extracellular GABA concentrations in the spinal cord in animals with and without joint inflammation.
The Journal of Neuroscience, 2007 • February 28, 2007
This study used transgenic mice expressing chondroitinase ABC (ChABC) to investigate the role of chondroitin sulfate proteoglycans (CSPGs) in limiting axonal regeneration after CNS injury. The researc...
KEY FINDING: Transgenic expression of ChABC allows CST axons to enter scar tissue after dorsal hemisection, but does not significantly improve motor function recovery.