Browse our collection of 12,052 research summaries, all carefully curated and simplified for the spinal cord injury community.
Showing 11,901-11,910 of 12,052 results
The Journal of Neuroscience, 2007 • February 28, 2007
This study demonstrates a PGE2-dependent, ERK1/2-regulated microglia–neuron signaling pathway that mediates the microglial component of pain maintenance after injury to the spinal cord. The researcher...
KEY FINDING: Phosphorylated ERK1/2 (pERK1/2), an upstream regulator of PGE2 release, is specifically localized to microglial cells in the lumbar dorsal horn after SCI.
PPAR Research, 2007 • February 28, 2007
This review discusses the roles of RAR/RXR and PPAR/RXR signaling pathways in physiological reactions after spinal cord injury, highlighting their potential as therapeutic targets. RAR signaling may i...
KEY FINDING: RAR signaling may improve axonal regeneration, influence glial differentiation, and modulate inflammatory reactions after spinal cord injury.
J Biol Chem, 2007 • February 23, 2007
The current study extends our understanding of how myelin inhibitors interact with the NgR family: NgR1 binds three linear segments of Nogo-A as well as MAG and OMgp; mutagenesis defined overlapping N...
KEY FINDING: RTN2 and RTN3 interact with NgR1 with nanomolar affinity, suggesting a role in myelin inhibition of axonal growth.
Journal of NeuroEngineering and Rehabilitation, 2007 • February 9, 2007
Modern gait rehabilitation emphasizes task-specific and repetitive training, moving away from tone-inhibiting approaches. Gait rehabilitation machines facilitate this by allowing patients to practice ...
KEY FINDING: The DEGAS study showed that machine-supported training (Gait Trainer GT I) resulted in superior gait ability and competence in activities of daily living compared to conventional gait training in stroke patients.
Journal of NeuroEngineering and Rehabilitation, 2007 • January 23, 2007
This study explores the use of biofeedback in robot-assisted gait training to improve patient performance and motivation. It addresses the challenge of reduced therapist-patient interaction in robotic...
KEY FINDING: Biofeedback values correlated well with the different activity levels of the subjects, indicating its potential to reflect gait performance accurately.
Spinal Cord, 2007 • January 1, 2007
This study investigates the effects of plantar cutaneous afferent excitation on the soleus H-reflex and flexion reflex in both subject groups while seated. Excitation of plantar cutaneous afferents re...
KEY FINDING: In SCI subjects, plantar cutaneous afferent stimulation facilitated the soleus H-reflex and late flexion reflex.
Neurorehabil Neural Repair, 2007 • January 1, 2007
Two multicenter randomized clinical trials (MRCT), the Extremity Constraint Induced Therapy Evaluation (EXCITE) to improve upper extremity function after stroke and the Spinal Cord Injury Locomotor Tr...
KEY FINDING: In EXCITE, the CIMT group increased the speed at which it completed a battery of standardized tasks with the affected hand compared to the control group that did not receive any therapy.
Neurorehabil Neural Repair, 2007 • January 1, 2007
The Spinal Cord Injury Locomotor Trial (SCILT) compared body weight-supported treadmill training (BWSTT) with conventional overground mobility intervention (CONT) in patients with incomplete traumatic...
KEY FINDING: No significant differences were found between body weight-supported treadmill training (BWSTT) and conventional overground mobility intervention (CONT) groups in terms of walking speed, Functional Independence Measure (FIM-L) for walking, and lower extremity motor score (LEMS).
Neurorehabil Neural Repair, 2007 • January 1, 2007
The purpose of this study was to determine whether long-term electrical stimulation training of the paralyzed soleus muscle could change the physiological properties of the soleus and influence tibia ...
KEY FINDING: Long-term electrical stimulation training of the paralyzed soleus muscle resulted in rapid and prolonged improvement in fatigue resistance.
J Biomech, 2007 • January 1, 2007
This study compared three mathematical muscle models (linear, 2nd order nonlinear, and Hill Huxley type nonlinear) for predicting force properties in trained and untrained paralyzed soleus muscles of ...
KEY FINDING: Nonlinear models, especially the Hill Huxley type, predict paralyzed muscle force properties more accurately than linear models.