Browse our collection of 12,052 research summaries, all carefully curated and simplified for the spinal cord injury community.
Showing 11,881-11,890 of 12,052 results
Radiation Oncology, 2007 • June 30, 2007
The review summarizes experimental strategies for preventing and treating radiation-induced CNS toxicity, including neurocognitive decline and radiation necrosis, highlighting the importance of tailor...
KEY FINDING: Early intervention with agents like amifostine and growth factors (IGF-1, FGF-2) shows preliminary evidence of modulating the radiation response in the CNS and increasing long-term radiation tolerance.
J Comp Neurol, 2007 • June 20, 2007
This study demonstrates that proximally axotomized spinal interneurons have the potential to form new connections via de novo axons from distal dendrites. A second set of CINs that were proximally axo...
KEY FINDING: Nearly half of the spinal commissural interneurons (CINs) had de novo axons that emerged from distal dendrites after axotomy.
The Journal of Neuroscience, 2007 • June 13, 2007
This study investigates the effects of inhibiting the epidermal growth factor receptor (EGFR) on recovery from spinal cord injury (SCI) in rats. The researchers used PD168393, a potent EGFR inhibitor,...
KEY FINDING: Treatment with PD168393, an EGFR inhibitor, significantly improved locomotor recovery, as indicated by higher BBB scores and BBB subscores compared to the control group.
Neurobiol Dis, 2007 • June 1, 2007
This study investigates the role of spinal microglia in the anti-allodynic and anti-hyperalgesic effects of electroacupuncture (EA) in a rat model of monoarthritis induced by Complete Freund’s Adjuvan...
KEY FINDING: Unilateral intra-articular injection of CFA produced a robust microglial activation and the up-regulation of the tumor necrosis factor (TNF)-α, interleukin (IL-1β), and IL-6 mRNA levels in the spinal cord.
Comp Biochem Physiol B Biochem Mol Biol, 2007 • June 1, 2007
The study isolated and characterized the axolotl orthologue of NPDC-1, a co-regulatory protein involved in retinoic acid signaling. Axolotl NPDC-1 shares structural and functional similarities with it...
KEY FINDING: Axolotl NPDC-1 mRNA expression peaks late in embryogenesis, coinciding with limb development, a process regulated by retinoic acid.
The Journal of Neuroscience, 2007 • May 30, 2007
The study investigates targeting regenerating sensory axons to normal synaptic locations in the spinal cord by combining positive and negative guidance molecules. NGF and semaphorin 3A treatment also ...
KEY FINDING: NGF overexpression leads to robust regeneration and sprouting of CGRP-positive nociceptive axons throughout the dorsal and ventral horns.
BMC Developmental Biology, 2007 • May 24, 2007
This study investigates the regeneration of neural crest derivatives, specifically melanophores and spinal ganglia, in the Xenopus tadpole tail after amputation. The findings indicate that melanophore...
KEY FINDING: Cells do not emigrate from the spinal cord during tail regeneration, indicating that a new neural crest is not induced as in embryonic development.
Neurosci Lett., 2007 • May 11, 2007
The study investigates the role of EphA4 receptor upregulation after spinal cord injury (SCI) in rats, examining its impact on axonal regeneration and nerve conduction. The researchers found that whil...
KEY FINDING: EphA4 protein levels initially decreased after SCI (2 and 4 DPI) and then increased at 7 DPI, with a tendency to further increase at 14 and 28 days.
Arch Phys Med Rehabil, 2007 • May 1, 2007
The study aimed to determine the frequency, severity, and course of seven symptoms in individuals with spinal cord injury (SCI) and their association with patient functioning. Postal surveys were used...
KEY FINDING: Pain, weakness, fatigue, and numbness were the most frequently reported symptoms among individuals with SCI.
Int J Dev Neurosci, 2007 • May 1, 2007
Demyelination is a hallmark of several neurological disorders, including multiple sclerosis (MS), spinal cord injury, and nerve compression. Therapeutic strategies aim to promote remyelination and pro...
KEY FINDING: Cell transplantation, using cells like oligodendrocytes, Schwann cells, and olfactory ensheathing cells (OECs), has demonstrated remyelination and improved conduction in animal models.