Browse our collection of 12,052 research summaries, all carefully curated and simplified for the spinal cord injury community.
Showing 11,531-11,540 of 12,052 results
J Clin Immunol, 2010 • May 1, 2010
The study identifies natural human IgM antibodies that can promote remyelination in animal models of demyelinating diseases like multiple sclerosis (MS). These antibodies bind to oligodendrocytes and ...
KEY FINDING: Two human IgMs (sHIgM22 and sHIgM46) were identified that promoted significant remyelination in TMEV-infected mice, suggesting potential therapeutic applications.
J Clin Immunol, 2010 • May 1, 2010
Spinal cord injury (SCI) involves a primary mechanical trauma followed by a secondary injury cascade, including neuroinflammation, that exacerbates the initial damage. Neuroinflammation, while importa...
KEY FINDING: IgG can modulate the immune response by inducing apoptosis in leukocytes, neutralizing components of the complement system, and inhibiting the activation of leukocytes.
J Neurosci Res, 2010 • May 1, 2010
The study investigates the potential of neural restricted precursors (NRP) and glial restricted precursors (GRP) to generate specific neuronal phenotypes in the injured spinal cord and extend axons to...
KEY FINDING: NRP/GRP grafts can generate glutamatergic and GABAergic neurons in the injured spinal cord, which are essential for repairing local interneuron circuits damaged by SCI.
Exp Neurol, 2010 • May 1, 2010
This study demonstrates that overexpression of NGF distal to a nerve bifurcation enhances the accuracy of sensory axon reinnervation following nerve transection in a rat femoral nerve model. The enhan...
KEY FINDING: NGF overexpression significantly increased the accuracy of saphenous branch axon reinnervation to the appropriate nerve branch.
Exp Neurol, 2010 • May 1, 2010
This study introduces an in vitro model of adult mammalian nerve repair, combining spinal cord slices with peripheral nerve grafts. The model allows for real-time imaging of axon regeneration and prec...
KEY FINDING: Adult nerve grafts remain viable in the co-culture system, maintaining their structure and function, as evidenced by Schwann cell morphology and growth factor expression.
J Tissue Viability, 2010 • May 1, 2010
The study introduces a rat model for pressure ulcers (PU) and deep tissue injury (DTI) that includes chronic spinal cord injury (SCI) and simulates bony prominence using an implant. Histological data ...
KEY FINDING: Chronic SCI significantly affects pressure-induced tissue injury in a rat PU model.
JOURNAL OF PALLIATIVE MEDICINE, 2010 • May 1, 2010
This retrospective study assessed the frequency of advance directives and DNR orders in 88 patients with MSCC requiring rehabilitation consultation. The study found low rates of advance care planning ...
KEY FINDING: Only 23% of patients had a living will, 31% had health care proxies, and 11% had either out-of-hospital DNR order and=or dictated DNR note.
Yonsei Med J, 2010 • May 1, 2010
This study investigated the correlation between respiratory muscle strength and cough capacity in patients with respiratory muscle weakness, specifically those with ALS, cervical SCI, and DMD. The res...
KEY FINDING: In SCI patients, FVC was significantly higher in the supine position compared to the sitting position.
Arch Phys Med Rehabil, 2010 • May 1, 2010
This review supports the use of anticonvulsants such as gabapentin or pregabalin for post-SCI neuropathic pain. Tricyclic antidepressants were supported by limited evidence in those patients with supe...
KEY FINDING: Gabapentin and pregabalin, anticonvulsant medications, have strong evidence for effectiveness in treating neuropathic pain post-SCI.
Cochrane Database of Systematic Reviews, 2010 • May 1, 2010
This Cochrane review assessed pharmacological interventions for acute heterotopic ossification. The review has been withdrawn from publication. Withdrawal was due to the review being out-of-date and t...
KEY FINDING: The review was withdrawn due to being substantially out-of-date.