Browse our collection of 12,052 research summaries, all carefully curated and simplified for the spinal cord injury community.
Showing 11,541-11,550 of 12,052 results
The Journal of Neuroscience, 2010 • April 28, 2010
This study investigates the role of keratan sulfate (KS) in functional recovery after spinal cord injury (SCI) using N-acetylglucosamine 6-O-sulfotransferase-1 (GlcNAc6ST-1)-deficient mice, which lack...
KEY FINDING: Mice lacking N-acetylglucosamine 6-O-sulfotransferase-1 (GlcNAc6ST-1), and thus deficient in keratan sulfate, exhibit significantly better motor function recovery after spinal cord injury, as measured by footfall tests, footprint tests, and Basso mouse scale locomotor scoring.
J Biomech, 2010 • April 19, 2010
This study optimized and evaluated proportional derivative (PD) controllers for stimulating arm muscles to achieve accurate and robust reaching movements in a computational arm model. The controllers ...
KEY FINDING: Optimized PD controllers can generate accurate and efficient arm movements in a biomechanical model.
Brain Res, 2010 • April 6, 2010
This study investigates how diffuse traumatic brain injury (TBI) affects the activation and reorganization of the whisker-barrel circuit in rats. The researchers hypothesized that the extent of functi...
KEY FINDING: Whisker somatosensory regions of the cortex and thalamus maintained cellular composition as visualized by Nissl stain.
Eur J Appl Physiol, 2010 • April 3, 2010
This study compared oxidative stress levels between individuals with SCI and able-bodied subjects and assessed the impact of FES exercise on oxidative stress in SCI patients. The results showed no sig...
KEY FINDING: Baseline levels of oxidative stress and antioxidative capacity were similar between individuals with SCI and able-bodied subjects, suggesting a preserved (anti)oxidative status in SCI under basal conditions.
Neuroscientist, 2010 • April 1, 2010
MMPs are implicated in both injury and recovery processes following CNS trauma. Early MMP activity is generally detrimental, promoting barrier dysfunction and inflammation, while later MMP activity mo...
KEY FINDING: MMP-9 is elevated early after injury and is associated with blood-brain barrier disruption and inflammation, while MMP-2 is upregulated later and involved in wound healing.
Neurosci Bull, 2010 • April 1, 2010
This study investigates the role of PKC in neurite outgrowth of spinal cord neurons in vitro. The researchers found that changes in m/c-PKC activity and PKC-βII expression were significantly correlate...
KEY FINDING: The ratio of membrane-bound PKC activity to cytoplasmic PKC activity (m/c-PKC) and PKC-βII expression in neurites were significantly correlated with neurite outgrowth.
Clin Exp Pharmacol Physiol, 2010 • April 1, 2010
Glypican-1 is a major high-affinity ligand of the Slit proteins. Slit-2 and glypican-1 mRNA are upregulated and coexpressed in reactive astrocytes of injured adult brain, suggesting their involvement ...
KEY FINDING: Several potent inhibitors of glypican–Slit interactions were identified, including a low molecular weight periodate-oxidized heparin with no significant anticoagulant activity.
Exp Neurol, 2010 • April 1, 2010
This study investigated the impact of functional electrical stimulation (FES) on cell regeneration in rats with spinal cord injuries (SCI). The research found that FES significantly increased cell bir...
KEY FINDING: FES significantly increased cell birth in the lumbar spinal cord of rats with spinal cord injuries, with an 82-86% increase observed in the injured ‘cell birth’ subgroup.
Arch Phys Med Rehabil, 2010 • April 1, 2010
This prospective cohort study examined menopause transition characteristics and symptom bother in women with and without spinal cord injury (SCI). Results suggested that women with SCI experience grea...
KEY FINDING: Women with SCI reported greater bother from somatic symptoms (like pain and bladder infections) and diminished sexual arousal compared to women without SCI.
The Journal of Neuroscience, 2010 • March 31, 2010
This study addresses the challenge of limited axon regeneration after CNS injury due to myelin and glial scar inhibition. A chemical screen of a novel triazine library identified four compounds that o...
KEY FINDING: A chemical screen identified four novel triazine compounds (A05, C05, F05, and H08) that overcome myelin-mediated inhibition of neurite outgrowth.