Browse our collection of 12,052 research summaries, all carefully curated and simplified for the spinal cord injury community.
Showing 11,521-11,530 of 12,052 results
Nat Med, 2010 • June 1, 2010
Spinal motoneurons compensate for the loss of brainstem-derived serotonin (5-HT) after spinal cord injury (SCI) by increasing the expression of constitutively active 5-HT2C receptor isoforms. This con...
KEY FINDING: Changes in post-transcriptional editing of 5-HT2C receptor mRNA lead to increased expression of 5-HT2C receptor isoforms that are spontaneously active without 5-HT.
Ann N Y Acad Sci, 2010 • June 1, 2010
After peripheral nerve injuries, monosynaptic connections from group I afferents and motoneurons become diminished in the spinal cord. Lingering motor dysfunction might be related to decreased connect...
KEY FINDING: Sensory afferent synapses retract from lamina IX, causing a permanent relocation of inputs and disconnection from motoneurons.
Ann N Y Acad Sci, 2010 • June 1, 2010
Neonatal spinalized rats can achieve autonomous weight-supported locomotion, unlike adult spinalized rats, suggesting greater plasticity in the developing nervous system. Trunk control, influenced by ...
KEY FINDING: Neonatal spinalized rats can develop autonomous weight-supported stepping, unlike adult spinalized rats.
Ann N Y Acad Sci, 2010 • June 1, 2010
The study reviews the changes within the spinal cord produced by reflex conditioning, the supraspinal areas, and spinal cord descending pathways involved in this learning process. Reflex conditioning ...
KEY FINDING: H-reflex conditioning produces plasticity at multiple sites in the spinal cord, including the motoneuron, GABAergic terminals, and Ia afferent synaptic connection.
Respir Physiol Neurobiol, 2010 • May 31, 2010
This study investigated the feasibility of using high-frequency spinal cord stimulation (HF-SCS) to activate intercostal muscles for artificial ventilation in dogs with spinal cord injury. The results...
KEY FINDING: High-frequency spinal cord stimulation (HF-SCS) can maintain artificial ventilation by activating intercostal muscles alone in dogs with spinal cord injury and bilateral phrenicotomy.
Eur Spine J, 2010 • May 25, 2010
This study presents comprehensive data on a large patient population with acute thoracolumbar spinal injuries. The study updates results and presents clinical outcomes of current operative treatment s...
KEY FINDING: Combined posteroanterior surgery led to the best correction of posttraumatic deformity.
Journal of NeuroEngineering and Rehabilitation, 2010 • May 21, 2010
This study introduces and evaluates a novel mechanomyogram (MMG)-driven switch controlled by small eyebrow movements for computer access, especially targeting individuals with severe physical disabili...
KEY FINDING: The MMG-driven switch achieved an average sensitivity of 99.7 ± 0.4% and specificity of 99.9 ± 0.1%.
Adv Funct Mater, 2010 • May 10, 2010
This study developed nanofibrous scaffolds with aligned nanofibers for nerve guidance and drug delivery in spinal cord. The scaffolds with rolipram increased axon growth through the scaffolds and in t...
KEY FINDING: Scaffolds with rolipram significantly improved hindlimb function after 3 weeks in rats with spinal cord injury.
The Journal of Clinical Investigation, 2010 • May 1, 2010
This study investigates the mechanisms by which folate promotes CNS axon regeneration after injury in rodents, focusing on the role of DNA methylation. The research demonstrates that injury induces Fo...
KEY FINDING: Spinal cord and peripheral nerve injury induces the expression of the high-affinity folate receptor Folr1, but not the low-affinity reduced folate carrier Rfc1.
The Journal of Clinical Investigation, 2010 • May 1, 2010
This commentary focuses on a study that explores the role of folate in CNS regeneration following injury, highlighting its epigenetic mechanisms, specifically DNA methylation. The reviewed study by Is...
KEY FINDING: Iskandar et al. found that after injury to somatosensory axons in rodents, there was an increase in the expression of the α-isoform of folate receptor 1 (FOLR1).