Browse our collection of 12,052 research summaries, all carefully curated and simplified for the spinal cord injury community.
Showing 11,461-11,470 of 12,052 results
Arch Phys Med Rehabil, 2010 • November 1, 2010
This study investigated the impact of various wheelchair tilt-in-space and recline angles on skin perfusion over the ischial tuberosity in individuals with spinal cord injury (SCI). The results sugges...
KEY FINDING: When combined with 100° recline, a 35° tilt-in-space significantly increased skin perfusion compared to sitting upright.
JOURNAL OF NEUROTRAUMA, 2010 • November 1, 2010
This study developed and characterized a graded model of C5 hemicontusion in adult male rats using a widely used rodent spinal cord impactor. Deficits in skilled and unskilled forelimb function and lo...
KEY FINDING: Graded cervical hemicontusion SCI induced quantifiable deficits in skilled and unskilled forepaw use and locomotion.
Brain Res Bull, 2010 • October 30, 2010
This study investigated whether L-dopa (DOPA), locomotor-like passive exercise (Ex) using a Motorized Bicycle Exercise Trainer (MBET), or their combination in adult rats with complete spinal cord tran...
KEY FINDING: At 5 Hz stimulation, FDD of the H-reflex in the Tx+Ex, Tx+DOPA and Ctl groups was significantly different from the Tx group (p<0.01).
PNAS, 2010 • October 26, 2010
The study investigates the role of cilia in injury and regeneration responses, focusing on the function of foxj1a, a transcriptional regulator of ciliagenes, in response to tissue damage and renal cys...
KEY FINDING: Zebrafish foxj1a, but not foxj1b, was rapidly induced in response to epithelial distension and stretch, kidney cyst formation, acute kidney injury, and crush injury in spinal cord cells.
Journal of Inflammation, 2010 • October 25, 2010
This study investigates the in vivo immuno-regulatory effectiveness of human mesenchymal stem cells (hMSCs) using an ovalbumin challenge model of acute asthma in mice. The results demonstrate a direct...
KEY FINDING: hMSCs are well tolerated in the murine model of acute asthma, suggesting that hMSCs can favorably change the outcome of asthmatic inflammation without the pathology associated with cross-species application.
Surgical Neurology International, 2010 • October 20, 2010
This review summarizes recent advances in translational neuroscience, covering topics from spinal cord regeneration and stroke recovery to brain tumor treatment and epilepsy management. The authors hi...
KEY FINDING: Pten deletion enhances regenerative ability of adult corticospinal neurons following spinal cord injury in animal models.
BMC Neurology, 2010 • October 20, 2010
The CONECSI trial evaluates a multidisciplinary cognitive behavioural programme for chronic neuropathic spinal cord injury pain (CNSCIP). The intervention aims to decrease pain intensity and related d...
KEY FINDING: The primary aim of the CONECSI trial is to evaluate the effects of a multidisciplinary cognitive behavioural treatment programme on pain intensity and pain-related disability
Journal of Tissue Engineering, 2010 • October 18, 2010
The review summarizes recent clinical trials involving pharmacological treatments and cell transplantations for spinal cord injury (SCI) patients. It evaluates recent in vivo studies focusing on vario...
KEY FINDING: Methylprednisolone can improve motor and sensory functions if applied within 8 hours of SCI, but it has detrimental effects and insufficient evidence.
Int J Qualitative Stud Health Well-being, 2010 • October 4, 2010
The study investigates the vulnerability and strength of spinal cord-injured patients during rehabilitation, using a phenomenological-hermeneutic narrative approach. Data collected from observations a...
KEY FINDING: Spinal cord injury significantly impacts various aspects of life, affecting physical and mental well-being and creating an imbalance between demands and resources.
TISSUE ENGINEERING: Part A, 2010 • October 1, 2010
This study investigates the effect of astrocyte alignment on neuronal growth using a 3D collagen gel culture system, finding that aligned astrocytes enhance neurite outgrowth. The researchers develope...
KEY FINDING: Astrocyte alignment is significantly greater at the edge and middle of tethered rectangular collagen gels compared to unaligned delta zones.