Browse our collection of 12,052 research summaries, all carefully curated and simplified for the spinal cord injury community.
Showing 11,451-11,460 of 12,052 results
Dev Dyn, 2010 • November 1, 2010
This paper presents a method for visualizing 3D relationships in intact and regenerating adult newt spinal cords using fluorescent probes and confocal microscopy. The method involves fixation, decalci...
KEY FINDING: PLP with 0.5% PFA fixative provided the best streptavidin probe penetration while preserving cellular morphology.
J Comp Neurol, 2010 • November 1, 2010
This study identifies aquaporin 1 (AQP1) as a distinguishing characteristic of olfactory ensheathing glia (OEG) in the mouse olfactory system. AQP1 is expressed by OEG in the lamina propria, olfactory...
KEY FINDING: AQP1 is expressed in olfactory ensheathing glia (OEG) in both peripheral and central olfactory structures.
Ann Neurol, 2010 • November 1, 2010
This study investigates the role of PTEN in oligodendrocytes, focusing on its impact on myelin formation and repair. The findings reveal that PTEN is essential for regulating myelin thickness and pres...
KEY FINDING: During development, loss of PTEN in oligodendrocytes leads to excessive myelin formation (hypermyelination).
J Neurosci Res, 2010 • November 1, 2010
This study demonstrates that injection of IKVAV-PA into the injured spinal cord consistently improves behavioral outcome in both rats and mice with different spinal cord injury models. The major poten...
KEY FINDING: IKVAV PA injection leads to a significantly higher density of serotonergic fibers caudal to the injury site in the chronically injured spinal cord.
Exp Neurol, 2010 • November 1, 2010
This study investigates the effects of cycling exercise on the expression of apoptosis-associated microRNAs (miRs) after spinal cord injury (SCI) in rats. SCI leads to increased expression of pro-apop...
KEY FINDING: SCI results in increased expression of miR Let-7a and miR16.
J Pain, 2010 • November 1, 2010
This study demonstrates that skin incision, even without direct nerve injury, induces the expression of axonal regeneration-related genes in adult rat spinal sensory neurons. The researchers observed ...
KEY FINDING: Skin incision led to a significant increase in ATF3 expression in DRG neurons.
JOURNAL OF NEUROTRAUMA, 2010 • November 1, 2010
The study examined the effects of Nogo Receptor (NgR) deletion and multimodal exercise training on recovery from incomplete cervical spinal cord injury (SCI) in mice. Results showed that NgR deletion ...
KEY FINDING: Exercise training improved performance on tasks specifically related to the training regimen, indicating a task-specific benefit.
JOURNAL OF NEUROTRAUMA, 2010 • November 1, 2010
This study investigates whether chondroitinase ABC infusion enhances axon sprouting and improves behavioral deficits after traumatic brain injury (TBI) in rats. Chondroitinase treatment increased axon...
KEY FINDING: Acute chondroitinase infusion decreased intact CSPGs and significantly increased pericontusional cortical grey and white matter GAP43-positive axon sprouting at 7 days post-injury.
J. Magn. Reson. Imaging, 2010 • November 1, 2010
The study aimed to determine if a 3D-MDEFT sequence, typically used for brain morphometry, could also provide reliable measures of spinal cord cross-sectional area (SCA). Images of the brain and cervi...
KEY FINDING: The 3D-MDEFT approach showed similar precision to standard methods for scan-rescan reproducibility of spinal cord area (SCA) measurements.
Arch Phys Med Rehabil, 2010 • November 1, 2010
This longitudinal study examined the incidence and risk factors associated with subsequent injuries among individuals with spinal cord injury (SCI) over a 10-year period. The study found a higher inci...
KEY FINDING: The annual incidence of subsequent injuries among individuals with SCI was found to be significantly higher than previously reported.