Browse the latest research summaries in the field of research methodology & design for spinal cord injury patients and caregivers.
Showing 661-670 of 702 results
J Transl Med, 2015 • November 14, 2015
This study introduces an efficient and reproducible method for preparing MSC media that avoids xenogenic components by mechanically depleting fibrinogen from pHPL, supporting heparin-free MSC propagat...
KEY FINDING: The clotting procedure reduced fibrinogen levels more than 1000-fold, with a high volume recovery of 99.5%.
Leukemia, 2016 • January 29, 2016
This study by the European Research Initiative on CLL (ERIC) identified and validated a flow-cytometric approach to reliably quantitate CLL cells to the level of 0.0010% (10 −5). A parallel analysis o...
KEY FINDING: A six-marker flow cytometry panel (CD19, CD20, CD5, CD43, CD79b, and CD81) was identified as reliable and convenient for identifying typical CLL cells.
BMJ Case Rep, 2016 • June 3, 2016
This case report describes a patient with myelomalacia (spinal cord damage) in the posterior funiculus associated with a ventral longitudinal intraspinal fluid collection (VLISFC). The underlying caus...
KEY FINDING: The patient presented with myelomalacia located in the posterior funiculus at C3 in addition to the anterior horn from C2 to C4.
Neural Plasticity, 2016 • April 18, 2016
This review explores the remarkable regenerative capacity of the zebrafish central nervous system (CNS), focusing on spinal cord repair. Unlike mammals, zebrafish can regenerate damaged spinal cords, ...
KEY FINDING: Zebrafish spinal cord regeneration involves a brief inflammatory response, macrophage activity to clear myelin debris, minimal cell loss, extensive neurogenesis, and a permissive environment for axonal regrowth.
Neural Regeneration Research, 2016 • June 1, 2016
This study aimed to improve animal models of chronic thoracolumbar cord compression using a progressive screw method. A custom-designed flat plastic screw was implanted in the spinal cord between thor...
KEY FINDING: Progressive screw compression successfully induced chronic thoracolumbar spinal cord injury in rats, as evidenced by motor function decline and stenosis.
Research and Reports in Urology, 2016 • September 28, 2016
The study successfully developed a CT-guided technique for tined lead implantation in minipigs for sacral neuromodulation. The procedure allows for precise targeting of the sacral nerve root S3, leadi...
KEY FINDING: Successful bilateral tined lead implantation was achieved in four out of five minipigs using the CT-guided technique.
International Journal of Molecular Sciences, 2016 • December 26, 2016
Stem cells represent a promising therapeutic approach for SCI, enhancing sensory and motor functions in animal models by promoting remyelination and axonal regeneration. Challenges remain in stem cell...
KEY FINDING: Stem cells can promote remyelination, neurite outgrowth, and axonal elongation after spinal cord injury.
BMC Res Notes, 2017 • January 18, 2017
This case report highlights the diagnostic challenges of cobalamin deficiency, particularly in patients with SACD, and emphasizes the importance of considering alternative markers like MMA and homocys...
KEY FINDING: Normal cobalamin serum levels do not rule out a cobalamin deficiency, especially in cases of SACD.
Int Neurourol J, 2017 • March 1, 2017
This study aimed to determine the structural changes of the urinary bladder after chronic SCI in minipigs, with a focus on the analysis of urinary bladder wall proteins and their quantitative distribu...
KEY FINDING: Chronic SCI significantly increased bladder wall thickness in minipigs.
Neural Regeneration Research, 2017 • May 1, 2017
This study introduces a novel method using low-energy two-photon nanosurgery to selectively disrupt individual dendrites, axons, and dendritic spines in the murine brain and spinal cord to accurately ...
KEY FINDING: Individual axons, dendrites, and dendritic spines in the brain and spinal cord were successfully ablated using low energy two-photon nanosurgery.