Browse the latest research summaries in the field of research methodology & design for spinal cord injury patients and caregivers.
Showing 601-610 of 702 results
Frontiers in Integrative Neuroscience, 2013 • November 26, 2013
Functional recovery is the most relevant outcome measure for spinal cord injury (SCI) treatments, but assessing it in animal models is challenging and often underestimated. Various factors, including ...
KEY FINDING: The percentage of spared spinal tissue is not always linearly related to an inverse decline in functional recovery.
PLoS ONE, 2013 • December 5, 2013
The study introduces a porcine model for developing and evaluating spinal stimulation techniques to restore motor function after spinal cord injury, addressing limitations of small animal models. The ...
KEY FINDING: Epidural and intraspinal stimulation in the porcine model successfully evoked selective extension, flexion, adduction, and abduction of the knee and hip joints.
Clin Trans Sci, 2014 • January 1, 2014
This study details the process of translating brain-computer interface (BCI) research from animal models to human clinical trials, specifically for upper limb motor neuroprostheses. Key elements inclu...
KEY FINDING: A participant with tetraplegia learned to control a sophisticated robotic arm with seven degrees of freedom (DOF) through a BCI, demonstrating skill and speed approaching that of an able-bodied person.
BMC Neurology, 2014 • March 13, 2014
This study investigates the facilitators and barriers to self-management among individuals with traumatic SCI, incorporating perspectives from patients, caregivers, and healthcare managers. The resear...
KEY FINDING: Physical and emotional support from caregivers significantly contribute to the well-being and self-management of individuals with traumatic SCI.
Frontiers in Human Neuroscience, 2014 • March 13, 2014
This review highlights that predicting walking recovery after SCI is possible based on patient demographics and clinical examination, particularly AIS classification. Instrumental examinations, like S...
KEY FINDING: Patients with complete sensory-motor lesions have very limited chances of regaining walking function, and if they do, they are often 'limited ambulators'.
J Clin Neuromuscul Dis, 2014 • June 1, 2014
This case report describes a young man with monomelic amyotrophy who experienced clinical improvement after avoiding sustained neck flexion. The patient's strength in the affected muscles improved aft...
KEY FINDING: The patient experienced improved strength in the right finger extensors, finger flexors, and wrist extensors after avoiding neck flexion for a year.
Crit Rev Phys Rehabil Med, 2013 • January 1, 2013
This review summarizes key predictors of post-stroke rehabilitation outcomes, highlighting the strengths and weaknesses of many studies to provide recommendations for providers of post-stroke rehabili...
KEY FINDING: Younger age is consistently associated with better outcomes after stroke rehabilitation.
Curr Protoc Essent Lab Tech, 2013 • January 1, 2013
Quantification of immunohistochemistry (IHC) and immunofluorescence (IF) using image intensity depends on a number of variables. These variables add a subjective complexity in keeping a standard withi...
KEY FINDING: FFT allows for an objective quantification of photomicrographs based on morphology, which reduces the subjectivity associated with pixel-intensity methods.
Journal of Neurotrauma, 2021 • August 1, 2021
The study tracked serological markers over one year following spinal cord injury, finding that most markers normalized within 6-12 months, with injury severity affecting these levels. Differences betw...
KEY FINDING: Most serological markers were at pathological levels at baseline but returned to normal values within 6–12 months post-injury.
Advanced Science, 2021 • February 25, 2021
This study investigates the potential of MgFe-LDH nanoparticles as a replacement for LIF in mESC culture, aiming to provide a chemically defined and xeno-free culture condition. The results demonstrat...
KEY FINDING: MgFe-LDH nanoparticles are superior to MgAl-LDH nanoparticles in maintaining mESC self-renewal and pluripotency under LIF and MEF-free conditions.