Browse the latest research summaries in the field of research methodology & design for spinal cord injury patients and caregivers.
Showing 611-620 of 702 results
Journal of Pathology Informatics, 2022 • December 20, 2022
This study investigates the use of generative adversarial networks (GANs) to enhance the quality of frozen section images by translating them into virtual paraffin sections, aiming to improve diagnost...
KEY FINDING: Pathologists' detection accuracy of virtual paraffin sections was between 0.62 and 0.97, indicating a challenge in distinguishing real from AI-generated images.
Clin Exp Immunol, 2021 • September 7, 2021
This review explores the proregenerative roles of Tregs in zebrafish and mammals, highlighting the FoxP3-dependent immunosuppressive function of Tregs in zebrafish as a useful model for future researc...
KEY FINDING: Zebrafish possess two FOXP3 orthologs, foxp3a and foxp3b, potentially serving a redundant role in Treg formation and activity.
Cells, 2021 • September 5, 2021
Human iPSCs have become a powerful tool in basic as well as translational and clinical research because of their ability to be maintained indefinitely whilst preserving the genetic makeup of the host. ...
KEY FINDING: iPSC-based disease models have been studied for cardiac channelopathies including hereditary long QT syndrome (LQTS), dilated cardiomyopathy (DCM), hypertrophic cardiomyopathy (HCM), and arrhythmogenic right ventricular cardiomyopathy (ARVC).
ONCOLOGY LETTERS, 2021 • January 1, 2021
The present study aimed to describe the clinical characteristics, and to construct and validate nomograms for patients with non‑metastatic Ewing sarcoma. Age, sex, tumor extension and surgery were in...
KEY FINDING: Age, tumor extension, sex, International Classification of Diseases for Oncology, 3rd Edition histology, surgery and chemotherapy were identified as independent risk factors for OS and CSS.
Neural Regen Res, 2022 • June 1, 2022
This study aimed to identify key genes and pathways involved in axon regeneration after spinal cord injury (SCI) in zebrafish to provide new targets for mammalian SCI treatment. RNA sequencing data an...
KEY FINDING: Zebrafish spontaneously recovered 44% of their swimming ability within the subacute phase (2 weeks) after spinal cord injury.
Cell Proliferation, 2022 • January 2, 2022
This study identifies Toll-7 as a proto-oncogene in Drosophila that promotes tumor growth and invasion. Toll-7 activates Egr-JNK and EGFR-Ras signaling pathways, leading to cell proliferation, tissue ...
KEY FINDING: Loss of Toll-7 suppresses tumor growth and invasion in a Drosophila model of RasV12/lgl−/−-induced tumors.
npj Regenerative Medicine, 2022 • January 1, 2022
This review summarizes the role of the Hippo pathway in zebrafish regeneration, noting that Yap1/Taz signaling often enhances regeneration through promoting cell proliferation, progenitor cell dediffer...
KEY FINDING: Hippo pathway effectors Yap/Taz facilitate zebrafish regeneration, suggesting therapeutic potential in promoting YAP/TAZ signaling to enhance mammalian regeneration.
STAR Protocols, 2022 • March 18, 2022
Zebrafish regenerate their spinal cord after injury, both at larval and adult stages. Larval zebrafish have emerged as a powerful model system to study spinal cord injury and regeneration due to their h...
KEY FINDING: The protocol details two methods for spinal cord transection: incision and perforation lesion, both yielding comparable regeneration kinetics with reproducibility, high throughput, and low mortality.
Diagnostics, 2022 • May 10, 2022
The study addresses the need for a sample storage buffer (SSB) that inactivates SARS-CoV-2 while preserving viral RNA for reliable diagnostics and sequencing. The developed guanidine-hydrochloride-bas...
KEY FINDING: The guanidine-hydrochloride-based storage buffer (SSB-4M) is compatible with commercially available and in-house GuHCl-based RNA extraction methods.
Front. Cell Dev. Biol., 2022 • June 29, 2022
This review examines the factors that regulate adult neural stem and progenitor cell (aNSPC) cell cycle dynamics in teleosts, particularly focusing on studies using the zebrafish model. It highlights h...
KEY FINDING: Social interactions, stress, hormones, diet, and sensory stimuli significantly influence aNSPC activity in the zebrafish CNS.