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Making Spinal Cord Injury (SCI) Research Accessible to Everyone. Simplified summaries of the latest research, designed for patients, caregivers and anybody who's interested.

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Research Methodology & Design Research

Browse the latest research summaries in the field of research methodology & design for spinal cord injury patients and caregivers.

Showing 41-50 of 702 results

SurgerySpinal DisordersResearch Methodology & Design

Paraparesis caused by intradural thoracic spinal granuloma secondary to organizing hematoma: illustrative case

J Neurosurg Case Lessons, 2022 • November 21, 2022

Spinal granulomas are rare inflammatory masses that can form within the spinal cord due to infectious or non-infectious processes. This case report details a unique instance of an intradural granuloma...

KEY FINDING: The authors present the first report of paraparesis caused by intradural granuloma secondary to organizing hematoma.

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SurgeryOrthopedicsResearch Methodology & Design

Bilateral persistent intersegmental artery in a patient with posterior atlantoaxial subluxation after subaxial cervical laminoplasty

International Journal of Surgery Case Reports, 2023 • January 1, 2023

This case report describes the successful management of an 85-year-old woman with posterior atlantoaxial subluxation and bilateral persistent first intersegmental artery (PFIA). The patient underwent ...

KEY FINDING: The patient had bilateral PFIA, a rare vascular anomaly, along with left-sided high-riding vertebral artery (HRVA).

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Spinal Cord InjuryOncologyResearch Methodology & Design

Efficacy and toxicity of primary re-irradiation for malignant spinal cord compression based on radiobiological modelling: a phase II clinical trial

British Journal of Cancer, 2023 • December 8, 2022

This phase II clinical trial evaluated the efficacy and toxicity of primary re-irradiation for malignant spinal cord compression (MSCC) using a biologically effective dose-based approach. The study fo...

KEY FINDING: Re-irradiation is an effective treatment for MSCC, with 81.8% of evaluable patients experiencing stable or improved mobility at 5 weeks post-treatment.

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Spinal Cord InjuryNeurologyResearch Methodology & Design

Protocol paper: kainic acid excitotoxicity‑induced spinal cord injury paraplegia in Sprague–Dawley rats

Biological Research, 2022 • November 2, 2022

This research paper details a protocol for inducing spinal cord injury (SCI) in Sprague-Dawley rats using kainic acid (KA). The method involves a precise intraspinal injection technique to create para...

KEY FINDING: Intraspinal injection of 0.05 mM kainic acid at a rate of 10 µL/min effectively induces spinal cord injury and paraplegia in rats.

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NeurologyPain ManagementResearch Methodology & Design

Sex-distinct microglial activation and myeloid cell infiltration in the spinal cord after painful peripheral injury

Neurobiology of Pain, 2022 • October 12, 2022

This study investigates sex-specific differences in spinal cord microglial activation and myeloid cell infiltration following peripheral injury using a mouse model of complex regional pain syndrome (C...

KEY FINDING: Spinal cord microglial activation is attenuated and delayed in females compared to males after peripheral injury.

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NeurologyResearch Methodology & Design

Bulbar onset amyotrophic lateral sclerosis: A case report

Annals of Medicine and Surgery, 2022 • November 13, 2022

This case report highlights the importance of early diagnosis in bulbar onset ALS, a rare and progressive neurodegenerative disease. A 60-year-old female with slurred speech and dysphagia was diagnose...

KEY FINDING: The presence of genioglossus muscle involvement at diagnosis implies a shorter survival for ALS patients.

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Spinal Cord InjuryNeurologyResearch Methodology & Design

Recombinant human erythropoietin plus methylprednisolone versus methylprednisolone in treatment of acute spinal cord injury:protocol for a systematic review and meta-analysis

BMJ Open, 2022 • January 1, 2022

This protocol outlines a systematic review and meta-analysis to evaluate the efficacy of recombinant human erythropoietin (rHuEPO) plus methylprednisolone (MP) compared to MP alone in improving neurol...

KEY FINDING: The primary outcome will be the American Spinal Injury Association score at the time of follow-up.

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NeurologySurgeryResearch Methodology & Design

Late-onset white cord syndrome following anterior cervical discectomy and fusion: A case report

EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2023 • January 1, 2023

This case report describes a patient who developed late-onset white cord syndrome (WCS) following anterior cervical corpectomy and fusion (ACCF) for cervical spondylotic myelopathy (CSM). The patient ...

KEY FINDING: The patient presented with late-onset WCS, developing paralysis on the 7th postoperative day after ACCF surgery for CSM.

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Spinal Cord InjuryHealthcareResearch Methodology & Design

Correction to: Development of a comprehensive assessment tool to measure the quality of care for individuals with traumatic spinal cord injuries

Spinal Cord Series and Cases, 2023 • July 1, 2023

This is a correction notice for a misspelling of the author name Roya Habibi Arejan in the original article. The original article concerns the development of a comprehensive assessment tool for measur...

KEY FINDING: The author name 'Roya Habibi Arejan' was corrected in the original article.

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Spinal Cord InjuryResearch Methodology & Design

Development of a Dynamic Nomogram for Predicting the Probability of Satisfactory Recovery after 6 Months for Cervical Traumatic Spinal Cord Injury

Orthopaedic Surgery, 2023 • April 1, 2023

The nomogram, including ASIA grade, the length of high signal in the spinal cord, MSCC, spinal segment fractured, admission time, and hormonal therapy within 8 h after injury, is a promising model to ...

KEY FINDING: The multivariate logistic regression model further screened out six independent factors that impact the recovery of patients with CTSCI.

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