Browse the latest research summaries in the field of research methodology & design for spinal cord injury patients and caregivers.
Showing 31-40 of 702 results
Contemporary Clinical Trials Communications, 2022 • September 3, 2022
This qualitative study investigated the experiences of patients participating in the PAPAartis clinical trial, which aims to prevent spinal cord injuries during thoracoabdominal aortic aneurysm repair...
KEY FINDING: Patients participate in clinical trials due to trust in doctors, hope for better treatment, and altruistic motives, but often struggle to understand the complex information provided.
J Neurosci Res, 2022 • September 1, 2022
Compression spinal cord injuries are a common cause of morbidity in people who experience a spinal cord injury (SCI). Either as a by-product of a traumatic injury or due to nontraumatic conditions su...
KEY FINDING: The review describes current animal models of compressive SCI and evaluated their broader applications. Models that are reproducible, uncomplicated, and adaptable across species and ages have the most potential for translational research.
Neurospine, 2022 • September 1, 2022
This meta-analysis assessed the impact of therapeutic hypothermia on patients with acute SCI, finding that hypothermia led to neurological improvement in over half of the patients. Systemic hypothermi...
KEY FINDING: Hypothermia in acute SCI improved neurological function in 55.8% of patients.
PLOS ONE, 2022 • October 18, 2022
This study evaluated the efficacy of topical oclacitinib, in conjunction with nail trimming, for treating murine ulcerative dermatitis (UD) compared to nail trimming alone or nail trimming combined wi...
KEY FINDING: Mean UD scores decreased from day 1 to day 7 and from day 1 to day 14 for all treatment groups, indicating improvement in skin lesions regardless of the treatment.
Neurourol Urodyn, 2023 • January 1, 2023
This study pooled data from two phase III clinical trials to assess the efficacy and safety of abobotulinumtoxinA (aboBoNT-A) in treating urinary incontinence due to neurogenic detrusor overactivity (...
KEY FINDING: A significant reduction was observed in mean NDOI episodes/week at Week 6 with both aboBoNT‐A doses versus placebo in the SCI (all p < 0.001) and MS (all p < 0.01) groups
Frontiers in Cardiovascular Medicine, 2022 • October 20, 2022
This meta-analysis compares the outcomes of conventional elephant trunk (ET) and frozen elephant trunk (FET) techniques for aortic arch surgery, focusing on early mortality and major complications. Th...
KEY FINDING: ET is associated with higher early mortality compared to FET (RR 1.37 [1.04 to 1.81], p = 0.027) when considering all studies published between 2008 and 2021.
Clinical and Translational Radiation Oncology, 2023 • January 1, 2023
This case report describes a patient with polycythemia vera who developed spinal cord compression due to extramedullary hematopoiesis and was successfully treated with radiotherapy. Radiotherapy, usin...
KEY FINDING: Radiotherapy effectively treated spinal cord compression caused by extramedullary hematopoiesis in a patient with polycythemia vera.
Cureus, 2024 • June 9, 2024
This systematic review and meta-analysis aimed to consolidate and assess the existing evidence regarding the efficacy of ultra-early decompression surgery in improving clinical outcomes after cervical...
KEY FINDING: The meta-analysis showed no statistically significant difference in neurological improvement between ultra-early (≤5 hours) and early (5-24 hours) decompression.
Annals of Medicine and Surgery, 2022 • September 15, 2022
This case report discusses a rare presentation of primary spinal non-Hodgkin lymphoma in a 32-year-old male who presented with symptoms of impending cauda equina syndrome. The patient was successfully...
KEY FINDING: Primary spinal epidural diffuse large B-cell lymphoma should be considered in patients presenting with back pain and signs of impending cauda equina syndrome.
International Journal of Surgery Case Reports, 2022 • November 11, 2022
This case report details the successful surgical removal of a bullet from the spinal canal of a 25-year-old gunshot wound victim, leading to improved neurological function. The patient underwent damag...
KEY FINDING: The patient, a 25-year-old male, presented with a gunshot wound to the left flank, resulting in hemodynamic shock and lethargy.