Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 931-940 of 2,298 results
International Journal of Molecular Sciences, 2021 • July 25, 2021
This study investigates the efficacy of autologous omentum, either as a flap or graft, on spinal nerve regeneration after contusive and transected SCI in rats. The results indicate that omental grafts...
KEY FINDING: Omental graft improved behavior scores significantly from the 3rd to 6th week after injury in contusive SCI rats.
International Journal of Molecular Sciences, 2021 • July 30, 2021
This study demonstrates that distinct preceding induction by activin A, BMP-4, CHIR, and VEGF in lipid-enriched APEL medium resulted in a significant increase of hiPSC-derived platelet production using...
KEY FINDING: A modified protocol including activin A and CHIR99021 significantly increased HEC differentiation, resulting in improved MK production.
International Journal of Molecular Sciences, 2021 • August 3, 2021
This review explores the mechanisms of growth cone guidance and canonical guidance cues, comparing pathfinding after axotomy in regenerative and non-regenerative animal models. Guidance cues play a cr...
KEY FINDING: Growth cones are specialized structures that guide axon growth by sensing the environment and regulating the cytoskeleton through guidance cues.
Stem Cell Research & Therapy, 2021 • July 12, 2021
This study investigates the safety and efficacy of combining autologous Schwann cells (SCs) and bone marrow-derived mesenchymal stem cells (MSCs) for treating subacute complete spinal cord injury (SCI...
KEY FINDING: The study found statistically significant improvements in sensory and neurological functions among patients who received the cell transplant.
Theranostics, 2021 • July 25, 2021
The study demonstrates the self-assembly of skin progenitor cells into vascularized spheroid floating skin organoids (FSOs) in vitro and properly stratified rapidly vascularized human skin in vivo. Hu...
KEY FINDING: Adult and iPSC-derived fibroblasts, keratinocytes, and endothelial progenitors can self-assemble into both planar human skin in vivo and spheroid-shaped skin organoids in vitro.
Neural Regeneration Research, 2022 • March 1, 2022
We reviewed the pleiotropic beneficial effects of the stable gastric pentadecapeptide BPC 157, three very recent demonstrations that may be essential in the gut-brain and brain-gut axis operation, and...
KEY FINDING: BPC 157 counteracted bilateral clamping of the common carotid arteries-induced stroke, sustained brain neuronal damages were resolved in rats as well as disturbed memory, locomotion, and coordination.
Neural Regeneration Research, 2022 • March 1, 2022
Traumatic spinal cord injuries (SCI) disrupt the connection between the brain and spinal cord neurons, leading to impaired movement. Axon regeneration has been considered the Holy Grail in SCI researc...
KEY FINDING: Netrin-1 promotes significant regeneration of axonal tracts localized at the white matter segment across the transected area.
Journal of Orthopaedic Translation, 2021 • June 9, 2021
Spinal cord injury results in permanent neurological impairments and carries a heavy socioeconomic burden. Accurately pathogenic mechanism and promising therapeutic targets remain unclear. CircRNAs ex...
KEY FINDING: Dysregulated circRNAs after SCI are enriched in neuronal signal transduction and inflammatory response.
Stem Cell Res Ther, 2021 • September 27, 2021
This study aimed to investigate the therapeutic effects of basic fibroblast growth factor (bFGF)-overexpressing human umbilical cord-derived mesenchymal stem cells (HUCMSCs) in mice with completely tr...
KEY FINDING: bFGF-overexpressing HUCMSCs met the standards and safety of MSCs for clinic use, indicating their potential for clinical translation.
Advanced Genetics, 2021 • May 3, 2021
Regeneration varies across the animal kingdom, with simpler vertebrates exhibiting greater regenerative capabilities than complex vertebrates. The review focuses on appendage, spinal cord, and heart r...
KEY FINDING: Nerves play a crucial role in organ regeneration across diverse species, influencing progenitor cell proliferation and differentiation through the production of promoting factors, suggesting an evolutionarily conserved role of nerves in regeneration across vertebrates.