Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 921-930 of 2,298 results
CNS Neuroscience & Therapeutics, 2021 • June 6, 2021
This study investigates the transplantation of a vascularized pedicle of hemisected spinal cord to bridge a gap created by removing a segment of the thoracic spinal cord in dogs. The use of PEG at the...
KEY FINDING: Motor function was partially restored in dogs that underwent the transplantation procedure with PEG treatment, as evidenced by the re-establishment of anatomic continuity and axonal sprouting.
npj Regenerative Medicine, 2021 • July 2, 2021
This study demonstrates that adult X. tropicalis can regenerate heart tissue after ventricular apex resection, primarily through cardiomyocyte proliferation. RNA-seq analysis identified Fosl1 as a key...
KEY FINDING: Cardiomyocyte proliferation greatly contributes to heart regeneration in adult X. tropicalis upon apex resection.
International Journal of Molecular Sciences, 2021 • July 11, 2021
This review summarizes recent insights into preclinical and clinical studies using stem cells and supportive drugs for chronic SCI, highlighting the challenges and potential of stem cell therapy. The ...
KEY FINDING: Exogenous neural stem cell (NSC) therapies hold promise due to their ability to differentiate into neurons, astrocytes, and oligodendrocytes, potentially regenerating neural circuits and providing trophic support.
Cells, 2021 • June 6, 2021
Mammals have poor long-distance axon regeneration and functional recovery after spinal cord injury, unlike zebrafish. Understanding the cellular and molecular basis of this difference is a focus of res...
KEY FINDING: Zebrafish can recover swimming activity after spinal cord injury because of axonal projections regrowing across the injury site. Hindering axonal regrowth experimentally prevents functional recovery, and re-transecting regenerated spinal cords abolishes restored swimming activity.
Frontiers in Cellular Neuroscience, 2021 • June 18, 2021
This review discusses the progress and challenges of using human Schwann cell (hSC) transplantation for spinal cord injury (SCI) treatment, highlighting the potential benefits and limitations of hSC-b...
KEY FINDING: hSC transplants are relatively understudied compared to rodent SCs, possibly due to the sophisticated resources and expertise needed for hSC culture from human nerves.
Front. Cell Dev. Biol., 2021 • July 6, 2021
Preclinical and clinical studies suggest that stem cells, their secretomes, and extracellular vesicles (EVs) are promising for treating neurodegenerative diseases, including spinal cord injury (SCI) a...
KEY FINDING: MSCs possess immunomodulatory and paracrine potential, releasing cytokines and factors that inhibit T cells, B cells, and natural killer cells.
Frontiers in Cell and Developmental Biology, 2021 • July 7, 2021
Extracellular vesicles are beneficial tools for delivering biomolecules in regenerative medicine, with a lower risk of complications compared to cell therapy. MSCs are a favorable source for cell-base...
KEY FINDING: Mesenchymal stem cell-derived exosomes can reduce infarct size in myocardial ischemia/reperfusion injury, implicating them in tissue repair.
EMBO Reports, 2021 • July 29, 2021
This study investigates the role of Regulator of Cell Cycle (RGCC) in neural stem cell (NSC) self-renewal and differentiation during neocortical development. The researchers found that RGCC is exclusi...
KEY FINDING: RGCC is exclusively expressed in NSCs in the developing mammalian neocortex.
eNeuro, 2021 • July 29, 2021
The study demonstrates that miR-21 and miR-199a-3p regulate axon growth by modulating the PTEN/mTOR pathway, which affects protein synthesis in neurons. Injury-induced alterations in miR-21 and miR-19...
KEY FINDING: miR-21 increases and miR-199a-3p decreases in DRG neurons after in vivo axotomy, suggesting injury-induced changes in these miRs.
EXPERIMENTAL AND THERAPEUTIC MEDICINE, 2021 • January 1, 2021
This study investigates the potential of oscillating field stimulation (OFS) to promote spinal cord injury (SCI) recovery by regulating the differentiation of endogenous neural stem cells (NSCs) in ra...
KEY FINDING: OFS enhances the differentiation of endogenous NSCs into neurons and oligodendrocytes after SCI in rats.