Regenerative Medicine Research

KEY FINDING: GelMA hydrogel improved exercise ability in mice with SCI. Mice treated with GelMA hydrogel had markedly higher total scores and sub-scores on the BMS compared to the model group.

KEY FINDING: The CatWalk system (CW) is reliable for assessing gait abnormalities and motor coordination in rodent models of nerve injuries.

KEY FINDING: NSPCs can potentially form relay circuits to bridge functional connectivity between injured spinal cord segments.

KEY FINDING: Changes in firing patterns of injured RS neurons began in as little as 2–3 days following injury, were maximal at ~2–3 weeks, and normal firing patterns were restored by 12–16 weeks.

KEY FINDING: RTN3 expression is higher in nerve cells that are regenerating after injury. We used qRT-PCR to demonstrate that RTN3 levels were upregulated by 4.2 ± 0.05- and 6.2 ± 0.04-fold in regenerating SN and pSN + DC DRGN compared to those harvested after DC injury

KEY FINDING: The study found increased bone formation at the defect site over six months, with 75-100% of the bone area showing formation. This suggests the stem cell and scaffold combination supports bone regeneration.

KEY FINDING: Spontaneous hindlimb locomotor recovery occurs in rats four weeks after spinal cord hemisection.

KEY FINDING: Model rats exhibited improved accuracy on the paretic side over time in beam-walking and ladder rung walking tasks after L4-to-L4 nerve root transfer.

KEY FINDING: BMSCs exosome injections improved Gli-1 and Shh levels in rats with SCI.

KEY FINDING: Zebrafish possess two FOXP3 orthologs, foxp3a and foxp3b, potentially serving a redundant role in Treg formation and activity.