Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 881-890 of 2,298 results
The Journal of Neuroscience, 2014 • September 17, 2014
The study investigates the interaction between neural stem cell transplantation (TP) and treadmill training (TMT) in a rat model of spinal cord injury (SCI). Results showed that combining TMT with NSC...
KEY FINDING: Combining treadmill training with neural stem cell transplantation synergistically improved locomotor function in rats with spinal cord injuries.
Neural Regen Res, 2012 • December 1, 2012
This research explores the selective control of bladder and erectile functions by specific posterior spinal nerve roots (L6 and S1) in rats, utilizing electrostimulation and pressure measurements. The...
KEY FINDING: Stimulation of certain posterior rootlets in L6/S1 significantly impacted bladder pressure, while others mainly affected urethral perfusion or intracavernous pressure.
Front Biol (Beijing), 2013 • October 1, 2013
Neurotrophins play vital roles in nerve regeneration following traumatic CNS injury, enhancing neuronal survival, axonal regrowth, remyelination, and synaptic plasticity. NT-mediated nerve regeneratio...
KEY FINDING: Neurotrophin treatments can induce sensory axonal regeneration after dorsal root lesions, promoting nerve regeneration and functional recovery from root avulsion injuries.
Neural Regen Res, 2012 • May 1, 2012
The study aimed to investigate the potential benefits of combining melatonin and exercise in alleviating ischemic brain damage in a rat model of focal cerebral ischemia/reperfusion injury. The finding...
KEY FINDING: Rats receiving melatonin combined with exercise exhibited more severe neurological deficits than those receiving melatonin or exercise alone after induced stroke.
Cell Medicine, 2011 • January 1, 2011
This study explored the mechanisms for functional recovery in SCI rats after intravenous transplantation of MSCs derived from human umbilical cord blood. MSC-treated rats showed a modest but significa...
KEY FINDING: MSCs transplantation resulted in modest but significant improvement in locomotor function of SCI rats.
Acta Neurochirurgica, 2021 • April 5, 2021
Herein, we found that BMSC-Shh-Exos were able to effectively protect rats against SCI-associated pathology by promoting neuronal functional recovery, survival, and by inhibiting the excessive activati...
KEY FINDING: Both BMSC-Exo and BMSC-Shh-Exo preparations significantly increased Shh expression in the spinal cord of SCI model rats and improved BBB scores in these treated animals.
Acta Neuropathologica Communications, 2021 • May 21, 2021
This study investigates the neurorestorative efficacy of repeated SCF + G-CSF treatment in the chronic phase of severe TBI, demonstrating its superiority over single treatments. The treatment enhances...
KEY FINDING: Repeated SCF + G-CSF treatments in the chronic phase of severe TBI lead to better neurological function improvement than single SCF + G-CSF treatment.
Biotechnol Bioeng, 2021 • July 1, 2021
This study combines biomaterial scaffolds, gene therapy, and stem cell transplantation to improve outcomes after spinal cord injury (SCI). Polyethylene glycol (PEG) hydrogel tubes are implanted into t...
KEY FINDING: IL-10 lentivirus-laden tubes improved E14 spinal progenitor survival, with an 11.5-fold increase in survival compared to mice receiving transplants without tubes.
Neurotherapeutics, 2021 • April 15, 2021
The study investigates the potential of a novel antisense oligonucleotide (NVP-13) to recondition the neurogenic niche in adult non-human primates by attenuating TGFβ signaling. NVP-13 effectively dow...
KEY FINDING: NVP-13 significantly downregulated TGFβ-RII mRNA and protein expression in vitro in human neural precursor cells.
Front. Cell Dev. Biol., 2021 • April 1, 2021
This study investigates the changes in gene expressions and DNA methylation during TSC derivation from NF, NT, and SNT blastocysts, identifying a set of 75 TFs whose transcription profiles can infer t...
KEY FINDING: Seventy-five transcription factors (TFs) are continuously upregulated during NF TSC derivation, and their transcription profiles can infer the time course of NF, but not NT, TSC derivation.