Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 871-880 of 2,298 results
J Comp Neurol, 2014 • June 15, 2014
This study investigates the expression of CSPG receptors PTPσ and LAR in lampreys after spinal cord injury, focusing on their role in axon regeneration and neuronal death. The researchers found that C...
KEY FINDING: CSPG immunoreactivity increases significantly near the lesion site at 2 weeks post-transection, then decreases.
BioMed Research International, 2013 • October 7, 2013
This study investigates the impact of intravenously infused mesenchymal stromal cells (MSCs) on functional outcome in a peripheral nerve injury model in rats. The results showed that intravenously inf...
KEY FINDING: Labelled MSCs were found in the sciatic nerve lesion site after intravenous injection, indicating a homing effect of the MSCs to the peripheral nerve lesion site.
International Journal of Molecular Sciences, 2014 • January 30, 2014
This study demonstrates a synergistic effect between melatonin treatment and physical exercise in a rat spinal cord injury model with behavioral improvement, histological recovery, and increased BrdU/...
KEY FINDING: The combination of melatonin and exercise significantly improved hindlimb function compared to the spinal cord injury group alone.
Molecular Brain, 2014 • March 10, 2014
The study investigated the effects of combining a semaphorin3A inhibitor (SM-345431) with treadmill training on axon regeneration and motor function recovery in rats with complete spinal cord transect...
KEY FINDING: SM-345431 treatment, using a novel drug delivery system, enhanced axon regeneration in the injured spinal cord.
Case Reports in Surgery, 2014 • March 11, 2014
This case report presents the outcomes of a 6-year-old girl with chronic spinal cord injury who underwent autologous BMMNCs transplantation along with standard rehabilitation. The patient exhibited im...
KEY FINDING: The patient showed clinical improvements, which was assessed using Functional Independence Measure (before: 82, after: 101 out of 126).
BMC Research Notes, 2014 • June 3, 2014
This technological report introduces a novel system capable of delivering localized compressive loads and/or vibration to human limbs, with demonstrated accuracy, repeatability, transmissibility, and ...
KEY FINDING: The limb loading system demonstrated high accuracy, with linearity, repeatability, and accuracy falling within 5%, 1%, and 1% of full scale, respectively.
Stem Cell Reports, 2014 • May 6, 2014
This study systematically assessed the detailed kinetics of NSC survival, migration, proliferation, and differentiation in the injured versus uninjured microenvironment, an issue that has received lit...
KEY FINDING: The injured microenvironment decreased the survival of transplanted hCNS-SCns compared to the uninjured spinal cord.
Neural Regeneration Research, 2013 • August 1, 2013
This study investigates the effects of combined GDAsBMP and hr-decorin transplantation on spinal cord contusion repair in rats. The findings suggest that this combined approach can inhibit inflammatio...
KEY FINDING: Combined transplantation of GDAsBMP and hr-decorin inhibited early inflammatory reactions and protected axons in rats with spinal cord contusion.
Neural Regeneration Research, 2013 • September 1, 2013
This study investigates how injury potentials after spinal cord injury can be modulated using electrical stimulation, with the injury potential serving as a parameter to adjust the intensity of the st...
KEY FINDING: The absolute values of injury potential in both the anode- and cathode-centered groups were much less than initial value of 100%.
Neural Regen Res, 2013 • February 1, 2013
This study explored the long-term effects of human umbilical cord blood stem cell therapy for chronic spinal cord injury, combining intravenous and direct epidural injection methods. The results indic...
KEY FINDING: Autonomic nerve functions were restored in some patients after stem cell transplantation.