Biotechnol Bioeng, 2021 · DOI: 10.1002/bit.27781 · Published: July 1, 2021
This study explores a new approach to treating spinal cord injuries (SCI) by combining biomaterials, gene therapy, and stem cells. The approach involves implanting polyethylene glycol (PEG) tubes loaded with a virus that delivers an anti-inflammatory protein (IL-10) into the injured spinal cord of mice. Two weeks later, spinal progenitor cells are injected into these tubes. The goal is to create a supportive environment that improves the survival and function of the transplanted cells, leading to better recovery after SCI. The results showed that this combined approach significantly improved the survival of the transplanted spinal progenitor cells, increased the formation of new neurons, and enhanced functional recovery in mice with spinal cord injuries.
The combination of IL-10 lentivirus and hydrogel tubes significantly enhances the survival rate of transplanted spinal progenitor cells, which is crucial for effective SCI treatment.
Surviving progenitor cells successfully differentiate into neurons, suggesting that the combined therapy supports the formation of new neural connections.
The study demonstrates a more rapid functional recovery in mice treated with the combined therapy compared to control groups, indicating the potential for improved clinical outcomes.