Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 811-820 of 2,298 results
The Journal of Neuroscience, 2017 • November 8, 2017
This study investigates the effects of post-injury ErbB2 activation in Schwann cells (SCs) on dorsal root (DR) axon regeneration using a doxycycline-inducible transgenic mouse line. The results demons...
KEY FINDING: Post-injury induction of caErbB2 in SCs selectively hyperactivates denervated, but not innervated, SCs, increasing their proliferation and prolonging their dedifferentiation.
American Journal of Pathology, 2018 • January 1, 2018
This review surveys the mechanisms leading to the formation of dystrophic growth cone at the injured axonal tip, the subsequent axonal dieback, and the molecular determinants of axon growth, plasticit...
KEY FINDING: Injured axons in the CNS often fail to regenerate and form dystrophic end bulbs, which persist at the lesion border.
Adv. Sci., 2017 • July 8, 2017
The study investigates the therapeutic potential of cerium oxide nanoparticles (CONPs) in treating spinal cord injury (SCI) in rats by reducing reactive oxygen species (ROS) levels. CONPs were found t...
KEY FINDING: CONPs suppressed iNOS generation and enhanced cell viability in H2O2-insulted cortical neurons in vitro.
J. Cell. Mol. Med., 2018 • January 1, 2018
This review discusses the therapeutic potential and pitfalls of FGFs in treating spinal cord injuries (SCI). FGFs have shown promise in preclinical studies, promoting functional recovery through vario...
KEY FINDING: aFGF, in conjunction with a peripheral nerve graft, was proven to have a beneficial effect in the reparation of complete thoracic spinal cord transection model in rodent.
JOURNAL OF NEUROTRAUMA, 2012 • May 20, 2012
This study investigates the effects of mesenchymal stem cell (MSC) transplantation on macrophage activation and functional recovery in rats after spinal cord injury (SCI). The results demonstrate that...
KEY FINDING: Transplanted MSCs migrate to the injury site but do not turn into nerve or glial cells.
Neural Regeneration Research, 2017 • October 1, 2017
This study investigates whether sensory nerves can induce motor nerve regeneration after end-to-side neurorrhaphy in rats. The results showed motor neuron regeneration occurred after cutaneous nerve e...
KEY FINDING: Acetylcholinesterase staining showed that 34% of myelinated axons were stained in the end-to-side group.
Exp Neurol, 2018 • February 1, 2018
The study examined the effects of neuronal activity, induced by KCl depolarization and electrical stimulation (ES), on axonal regeneration after spinal cord injury (SCI). In vitro experiments showed t...
KEY FINDING: KCl-induced depolarization can either inhibit or enhance neurite growth of DRG neurons depending on the duration and timing of the exposure.
MOLECULAR MEDICINE REPORTS, 2018 • January 1, 2018
This study investigates the potential of transplanting acellular spinal cord scaffolds (ASCs) seeded with rat adipose-derived stem cells (rADSCs) to treat spinal cord injury (SCI) in rats. The hypothe...
KEY FINDING: Rat ADSCs (rADSCs) were successfully isolated and characterized, expressing specific cell surface markers and demonstrating the ability to differentiate into osteocytes and adipocytes.
Neural Regeneration Research, 2017 • November 1, 2017
This study investigates the potential of globose basal cells (GBCs) from the olfactory epithelium for spinal cord regeneration. GBCs were isolated, characterized, and transplanted into rats with spina...
KEY FINDING: Globose basal cells (GBCs) expressed neural stem cell markers (nestin, SOX2, NCAM) and mesenchymal stem cell markers (CD29, CD54, CD90, CD73, CD105).
Scientific Reports, 2018 • January 10, 2018
This meta-analysis evaluated the effects of OEC transplantation on neuropathic pain for the first time, finding that longer follow-up periods were associated with reports of OEC transplantation negati...
KEY FINDING: OEC transplantation significantly improves functional recovery post-SCI in animal models.