Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 801-810 of 2,298 results
Surgical Neurology International, 2010 • December 25, 2010
This review article discusses the potential of stem cell transplantation for spinal cord regeneration, highlighting the limitations of current management options for SCI and the underlying mechanisms ...
KEY FINDING: Olfactory ensheathing cells (OECs) appear to be the most promising stem cell type for spinal cord regeneration due to their supportive role in axonal regeneration.
Cell Mol Neurobiol, 2011 • January 22, 2011
The study cloned rat TLX cDNA and demonstrated that ectopic expression of TLX enhanced DMSC cell growth and shifts differentiation of DMSCs into neuronal rather than astrocytic phenotypes in vitro. TL...
KEY FINDING: TLX promotes the proliferation of DMSCs. TLX/DMSCs showed enhanced proliferation compared to parental DMSCs.
Exp Neurol, 2011 • May 1, 2011
This study provides evidence that olfactory ensheathing glia (OEG) can facilitate axonal regeneration after a complete spinal cord transection in rats, leading to improved hindlimb function. The resea...
KEY FINDING: OEG-injected rats showed recovery of motor evoked potentials (MEP), indicating functional regeneration of axons across the complete spinal cord transection.
Journal of Tissue Engineering, 2010 • October 18, 2010
The review summarizes recent clinical trials involving pharmacological treatments and cell transplantations for spinal cord injury (SCI) patients. It evaluates recent in vivo studies focusing on vario...
KEY FINDING: Methylprednisolone can improve motor and sensory functions if applied within 8 hours of SCI, but it has detrimental effects and insufficient evidence.
Cell Medicine, 2010 • January 1, 2010
Cell-based restorative treatment has become a new trend, and increasing data worldwide have strongly proven that it has a pivotal therapeutic value in CNS disease. Functional neurorestoration has been...
KEY FINDING: The emergence of the term “neurorestoratology,” however, signals the birth of a new discipline, which is equally important in comparison with neurology and neurosurgery
PLoS ONE, 2011 • March 18, 2011
The study demonstrates that transplantation of SENAs overexpressing L1 enhances functional recovery after spinal cord injury in mice. L1 overexpression improves survival and migration of grafted SENAs...
KEY FINDING: L1 overexpressing SENAs improve locomotor function after transplantation into the lesioned spinal cord in mice.
The Journal of Spinal Cord Medicine, 2011 • January 1, 2011
This case report investigates the use of sustained release platelet-rich plasma (PRP) therapy for treating chronic stage IV pressure ulcers in three veterans with spinal cord injuries. The PRP treatme...
KEY FINDING: PRP treatment consistently resulted in the formation of granulation tissue, which is essential for wound healing.
Cell Mol Neurobiol, 2012 • August 11, 2011
The study investigates the use of human neural stem cells (hNSC) to promote functional recovery and structural reconnection in a rat model of complete spinal cord transection. The transplantation of h...
KEY FINDING: Transplanted hNSCs can differentiate into astrocytes and neurons at the injury site in the spinal cord.
The Journal of Immunology, 2017 • August 1, 2017
This study investigates the impact of innate immune components on human neural stem cell (hNSC) fate and migration. It was found that polymorphonuclear leukocytes (PMN) secrete factors that induce ast...
KEY FINDING: Conditioned media from polymorphonuclear leukocytes (PMN) selectively increased hNSC astrogliogenesis and promoted cell migration in vitro.
J Korean Neurosurg Soc, 2017 • July 1, 2017
This study examined the additive effects of GCSF on ADSC infusion in treating acute SCI in rats. The results indicated that ADSCs alone improved functional recovery, but the addition of GCSF did not s...
KEY FINDING: ADSC and ADSC+GCSF groups showed significantly higher Basso-Beattie-Bresnahan scores than the Sham group during 8 weeks.