Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 821-830 of 2,298 results
BioMed Research International, 2017 • November 19, 2017
This study investigates the apoptotic process in lamprey descending neurons after spinal cord injury (SCI), focusing on caspase activation and the involvement of the intrinsic apoptotic pathway. The r...
KEY FINDING: A significant correlation was found between the level of activated caspases (cell death markers) in identifiable neurons and their known regenerative ability after spinal cord injury in lampreys.
Asian Spine J, 2018 • December 1, 2018
This study investigates the therapeutic potential of olfactory ensheathing cell (OEC) transplantation in a rat model of spinal cord injury (SCI). OECs were cultured, characterized, and transplanted at...
KEY FINDING: Cultured olfactory ensheathing cells expressed markers for OECs (p75NTR), olfactory nerve fibroblasts (anti-fibronectin), Schwann cells (S100β), and astrocytes (GFAP).
Neural Regen Res, 2018 • January 1, 2018
Stem cell therapies hold promise for spinal cord injury (SCI) treatment, with several cell types in clinical trials. While not a panacea, these therapies, combined with other approaches, offer potenti...
KEY FINDING: Olfactory ensheathing cells (OECs) have shown promising results in preclinical studies and early clinical trials, with some patients experiencing functional recovery after transplantation.
Neural Regen Res, 2018 • February 1, 2018
This study investigates the molecular mechanisms by which electrical stimulation (ES) promotes neural regeneration in spinal cord-injured rats. The results indicate that ES can modulate the p38-RhoA a...
KEY FINDING: Electrical stimulation significantly shortened the latencies of somatosensory-evoked potentials (SSEPs) in rats with spinal cord injuries.
Brain Sci., 2018 • April 14, 2018
This study investigates the relationship between axon resealing, neuron size, and retrograde neuronal death after spinal cord injury (SCI) in lampreys. The findings suggest that larger neurons with sl...
KEY FINDING: Larger reticulospinal (RS) neurons have a lower probability of axon regeneration after spinal cord transection (SCI).
International Journal of Applied and Basic Medical Research, 2018 • October 1, 2018
This study investigates the combined therapeutic effects of olfactory ensheathing cells (OECs), mesenchymal stem cells (MSCs), and chondroitinase in a rat model of spinal cord injury (SCI). The prima...
KEY FINDING: All treated groups showed hindlimb motor recovery, evidenced by improved BBB scores, except for the control group.
Exp Neurol, 2018 • August 1, 2018
This study investigates the role of RhoA in retrograde neuronal death after spinal cord injury (SCI) in lampreys. The findings indicate that RhoA activation, rather than its mRNA expression, correlate...
KEY FINDING: RhoA mRNA is widely expressed in normal lamprey brain, with only slightly higher expression in poorly-regenerating neurons compared to good regenerators.
PNAS, 2018 • May 29, 2018
The study provides evidence that in monkeys with severe SCI, a bioactive and biodegradable material, NT3-chitosan, elicited robust de novo neural regeneration. Functional improvements were demonstrate...
KEY FINDING: NT3-chitosan elicited robust axonal regeneration, including long-distance axonal growth of cortical motor neurons in the cortical spinal tract.
Inflammation and Regeneration, 2020 • October 7, 2020
Spinal cord injury (SCI) is a devastating event that causes permanent neurologic impairments. Cell transplantation therapy using neural precursor cells (NPCs) is a promising intervention aiming to rep...
KEY FINDING: Grafted NPCs differentiated into three neural lineages without tumor formation. The differentiated oligodendrocytes enhanced remyelination for host neuronal axons and induced neurite regrowth of 5-HT+ serotonergic fibers around the lesion area, which led to locomotor functional recovery.
CNS Neurosci Ther, 2019 • January 1, 2019
This study aimed to find a feasible strategy to preserve ChABC catalytic activity using stabilizing agents. The study demonstrated that a 2.5 mol/L sucrose solution best stabilized ChABC as far as 14 ...
KEY FINDING: A 2.5 mol/L sucrose solution best stabilized ChABC activity in vitro for up to 14 days.