Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 711-720 of 2,298 results
Neural Regeneration Research, 2015 • August 1, 2015
This study aimed to validate neuroprotective effects of combined therapy (propofol and bone marrow mesenchymal stem cells (BMSCs)) on rat spinal cord injury. Results indicate that propofol can enhance...
KEY FINDING: Combined propofol and BMSC transplantation significantly improved hindlimb motor function in rats with spinal cord injury compared to monotherapy.
The Journal of Spinal Cord Medicine, 2022 • June 18, 2020
This study investigated the feasibility of restoring the penile sensory pathway in rats with spinal cord injury using end-to-side dorsal root transfer neurorrhaphy. The results showed that the procedu...
KEY FINDING: Neural labeling tests indicated the integrity of the rebuilt penile afferent pathway, suggesting a successful reconnection of nerves.
Neural Regeneration Research, 2021 • July 1, 2021
The study describes a pre-clinical spinal cord motor neuron injury model that is minimal invasive, reproducible, focal and easily applied to small rodents. Retrograde axonal transport of a pro-apoptot...
KEY FINDING: Retrograde axonal transport of wortmannin via the sciatic nerve results in a dose-dependent loss of ipsilateral lumbar motor neurons.
Biological Reviews, 2021 • December 17, 2020
This review discusses the cells and molecules involved in establishing a regenerative niche at the neuromuscular junction (NMJ) to promote motor function recovery after injury. It emphasizes the impor...
KEY FINDING: A regenerative niche at the mature NMJ must ensure the arrival of regenerating axons to denervated postsynaptic muscle domains for reinnervation.
Neural Regeneration Research, 2021 • September 1, 2021
This study fabricated a conductive graphene oxide composited chitosan scaffold and transplanted it into a T9 total resected rat spinal cord. The results show that the chitosan-graphene oxide scaffold ...
KEY FINDING: The chitosan-graphene oxide scaffold induces nerve cells to grow into the pores between chitosan molecular chains, inducing angiogenesis in regenerated tissue, and promote neuron migration and neural tissue regeneration in the pores of the scaffold, thereby promoting the repair of damaged nerve tissue.
Neural Regeneration Research, 2021 • January 7, 2021
This research investigates the potential of ISP and PAP4 peptides to promote motor functional recovery following peripheral nerve injury, specifically brachial plexus injury, in a rat model. The study...
KEY FINDING: ISP and PAP4 treatments significantly increased the survival of motoneurons in rats with brachial plexus injury.
Neural Regen Res, 2021 • August 1, 2021
This study investigates the potential of olfactory ensheathing cell (OEC) transplantation to promote axonal regeneration after spinal cord injury (SCI) in a rat model. The key findings indicate that O...
KEY FINDING: OEC transplantation partially restored locomotor function in rats with spinal cord injury, as evidenced by increased BBB scores at 6 and 8 weeks post-transplantation.
Cellular and Molecular Neurobiology, 2022 • January 22, 2021
This study investigated the beneficial effects of IGF-1 on spinal-transected zebrafish, showing that IGF-1 expression levels decreased after spinal transection. Down-regulation of IGF-1 expression inh...
KEY FINDING: IGF-1 expression is downregulated in the lesion site after spinal cord transection in zebrafish.
Neurospine, 2021 • June 1, 2021
Spinal cord injuries present with a complex series of molecular cascades that ultimately induce cell death of neurons and glia and excitotoxicity of astrocytes, limiting the effect of therapeutic inte...
KEY FINDING: RIPK1 exhibits pleiotropic effects contributing to the exacerbation of SCI and sufficient evidence supports the therapeutic utility of RIPK1 inhibitors.
Neural Regeneration Research, 2021 • September 1, 2021
Tissue or organ regeneration is a complex process with successful outcomes depending on the type of tissue and organism. Recent discoveries on the innate immune system ability to modulate stem cells f...
KEY FINDING: An acute and transient inflammation response is necessary to induce stem cell proliferation.