Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 721-730 of 2,298 results
The Journal of Neuroscience, 2021 • April 14, 2021
The study investigates how to harness the beneficial aspects of neuroinflammation to promote regeneration, focusing on macrophages and microglia. It reveals that the combination of LPS (a pro-inflamma...
KEY FINDING: The combination of LPS and regulatory IL4 and IL13 signaling in macrophages and microglia produces a reparative phenotype devoid of pro-inflammatory neurotoxic features.
Biochemistry and Biophysics Reports, 2021 • February 22, 2021
The study aimed to assess the effects of canine MSC CM on murine SCSC, focusing on cell survival, astrocyte reactivity, CSPG levels, and neuronal cell processes. Results indicated that MSC CM enhanced...
KEY FINDING: MSC CM increased astrocytic reactivity, as evidenced by increased GFAP immunostaining and astrocytic process length in SCSC compared to control medium.
G3, 2021 • March 20, 2021
The study combines high-efficiency CRISPR/Cas9 mutagenesis with functional phenotypic screening to identify genes required for spinal cord repair in adult zebrafish. Seventeen genes were targeted, and...
KEY FINDING: CRISPR/Cas9 dual-guide ribonucleic proteins (dgRNPs) can achieve selective and combinatorial mutagenesis of 17 genes at 28 target sites with efficiencies exceeding 85% in adult F0 crispants.
Top Spinal Cord Inj Rehabil, 2015 • January 1, 2015
As a scientific community, we have accomplished many things regarding the pathophysiology and treatment of SCI. These are exciting times in the field with many disciplines coming together to help targ...
KEY FINDING: Early decompression surgical procedures after severe SCI have been examined in both preclinical and clinical studies. Evidence suggests that these early surgical interventions are safe and effective, and they are currently recommended as an early intervention for patients with acute severe SCI.
TISSUE ENGINEERING: Part A, 2021 • May 28, 2021
This study investigates the spatial relationships between regenerating axons and blood vessels within hydrogel scaffolds implanted into spinal cord injuries in rats. The findings revealed that Schwann...
KEY FINDING: Scaffolds containing Schwann cells (SCs) significantly enhanced axonal regeneration and blood vessel formation compared to Matrigel-only (MG) or SCs with rapamycin (RAPA).
Bioactive Materials, 2021 • March 9, 2021
The study demonstrates that cyclic mechanical loading can modulate the immunoinflammatory microenvironment and stimulate osteogenic differentiation of MSCs seeded on 3D scaffolds. ECM-based scaffolds ...
KEY FINDING: Mechanical loading downregulated inflammatory mediators (IL1B and IL8) and upregulated osteogenic markers (ALP and COL1A1) in MSCs seeded on scaffolds.
CNS Neuroscience & Therapeutics, 2021 • July 1, 2021
This study investigates the role of EphB2 in astroglial-fibrotic scar formation after spinal cord injury (SCI) in rats. The researchers used RNA interference (RNAi) to knockdown EphB2 expression and a...
KEY FINDING: RNAi effectively reduced EphB2 expression after spinal cord injury, inhibiting the aggregation of fibroblasts and astrocytes.
NEURAL REGENERATION RESEARCH, 2021 • November 1, 2021
This study investigates the use of a decellularized optic nerve (DON) scaffold seeded with neurotrophin-3 (NT-3)-overexpressing Schwann cells (SCs) to promote directional axon regeneration and remyeli...
KEY FINDING: Porcine decellularized optic nerve (DON) scaffolds exhibit uniformly distributed straight channels and microscopic pores, conducive to neural stem cell adhesion, survival, and migration.
Neural Regen Res, 2021 • March 25, 2021
This study introduces a novel porous collagen scaffold with axially-aligned luminal conduits as a nerve regenerative material for SCI repair. The scaffold, loaded with NSCs, markedly improved locomoto...
KEY FINDING: The collagen scaffold enhances neural stem cell activity and promotes cell extension without affecting cell differentiation in vitro.
Stem Cell Research & Therapy, 2021 • April 19, 2021
This study demonstrates that exosomes derived from miR-26a-modified mesenchymal stem cells (MSCs) can effectively promote axonal regeneration and functional recovery in a rat model of spinal cord inju...
KEY FINDING: Exosomes derived from miR-26a-modified MSCs (Exos-26a) promote axonal regeneration in a rat model of spinal cord injury.