Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 701-710 of 2,298 results
Acta Biomater, 2015 • December 1, 2015
The study combined cell transplantation, neurotrophic factor delivery, and anti-inhibitory molecule delivery in fibrin scaffolds to treat spinal cord injury (SCI). The aim was to improve recovery by r...
KEY FINDING: pMN survival was not affected by the combination therapy with AIMS in vitro.
PLoS ONE, 2015 • September 22, 2015
This study demonstrates that high-dose ChABC treatment in the sub-acute stage of SCI effectively improves glial scar digestion by reducing the lesion size and increasing axonal regrowth to the related...
KEY FINDING: Intraparenchymal injection of high-dose ChABC in sub-acute SCI does not induce subarachnoid hemorrhage.
Stem Cell Research & Therapy, 2015 • January 1, 2015
This commentary discusses a study that demonstrates the transdifferentiation of differentiated MSCs contributes to remyelination of injured/regenerating axons. The study highlights the importance of N...
KEY FINDING: The interaction between NT-3 and TrkC is crucial for improving the transdifferentiating potential of rMSCs into neural-like cells.
PNAS, 2015 • October 27, 2015
The study investigates the potential of NT3-chitosan biomaterial to promote regeneration and functional recovery after spinal cord injury (SCI) by activating endogenous neural stem cells (NSCs). Resul...
KEY FINDING: NT3-chitosan, when inserted into a 5 mm gap of completely transected and excised rat thoracic spinal cord, elicited robust activation of endogenous neural stem cells.
PNAS, 2015 • October 27, 2015
The study uses gene expression analysis to understand the mechanisms behind NT3-chitosan induced spinal cord regeneration. Weighted gene co-expression network analysis (WGCNA) was used to establish ge...
KEY FINDING: Enhanced neurogenesis and angiogenesis, along with reduced inflammatory responses, are key to the regenerative effect of NT3-chitosan.
Cell and Tissue Research, 2022 • June 2, 2021
This review summarizes the regeneration potential of the CNS across different species and ages, highlighting the role of scar-like structures in this process. It discusses how next-generation sequenci...
KEY FINDING: Single-cell RNA sequencing reveals that the glial scar penumbra is rich in proliferating oligodendrocyte progenitor cells, significantly contributing to CSPG deposition and lesion site remodeling.
Dev Dyn, 2021 • June 1, 2021
Salamanders possess remarkable regenerative abilities, and the immune system plays a crucial role in these processes. Both innate and adaptive immune components are involved, with macrophages being pa...
KEY FINDING: Macrophages are recruited to the regenerating limb and heart, contributing to ECM remodeling, clearance of cellular debris and senescent cells.
Scientific Reports, 2015 • October 14, 2015
This study investigates the potential of modulating the proteoglycan receptor PTPσ with ISP to enhance regeneration and functional recovery after spinal root avulsion injury. The results demonstrate t...
KEY FINDING: ISP treatment significantly increased motor functional recovery after spinal root avulsion and re-implantation, as measured by the Terzis grooming test.
The Journal of Neuroscience, 2015 • October 14, 2015
Transcriptomic approaches are used to identify molecular mechanisms for neural repair. RNA-Seq technology improves the ability to understand gene expression network regulation. Activation of a core tr...
KEY FINDING: RNA-Seq technology improves the ability to understand gene expression network regulation, because it can identify isoform-specific gene regulators. This allows defining precise transcription start sites and 3' untranslated regions for each differentially expressed isoform.
Dev Biol, 2015 • December 1, 2015
This study investigates the response of ependymoglial cells to spinal cord injury in axolotls, focusing on the role of membrane potential dynamics in regeneration. The research demonstrates that spina...
KEY FINDING: Spinal cord injury induces a rapid and dynamic change in the resting membrane potential of ependymoglial cells in axolotls.