Regenerative Medicine Research

KEY FINDING: NPC transplants are a potential pro-regenerative therapy that elicits a robust host axonal regeneration and extensive axonal extension from transplant-derived neurons.

KEY FINDING: Neuro-PEG treatment led to the recovery of motor function in pigs after complete spinal cord transection.

KEY FINDING: The combined therapy significantly improved host-derived neuronal and oligodendrocyte differentiation at the SCI epicenter.

KEY FINDING: Transplanted NPCs secrete neurotrophic factors to attenuate secondary damage and differentiate into neurons that establish synaptic connections with host axons, contributing to functional recovery after SCI.

KEY FINDING: SRF expression increases after spinal cord injury (SCI) and promotes axonal regeneration.

KEY FINDING: MenSCs treatment improves motor function recovery and reduces spinal cord lesion volume in SCI rats.

KEY FINDING: The study demonstrated that AD-MSC harvesting and administration were well-tolerated in patients with traumatic SCI.

KEY FINDING: The United States leads in the number of published articles on AI research in spinal cord neural injury and restoration.

KEY FINDING: The average duration between injury and AD-MSC injection was corrected to 12 months (range of 7–22).

KEY FINDING: Both BMP4 alone and bFGF/BMP4 combination induce a quiescent state in neural stem cells (qNSCs), but they result in different levels of quiescence.