Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 551-560 of 2,298 results
Cell Transplantation, 2024 • June 1, 2024
This study aimed to determine the optimal MSCs transplantation strategy for treating SCI by conducting a network meta-analysis of animal studies. The analysis of 32 animal studies revealed that MSCs i...
KEY FINDING: MSCs transplantation improves motor ability after SCI in animal models compared to controls.
Arch Bone Jt Surg, 2024 • June 1, 2024
Spinal cord injury (SCI) is a complex and incurable condition causing significant damage. While advancements in managing SCI have improved, a complete treatment for humans remains elusive due to the i...
KEY FINDING: The pathophysiology of SCI consists of a two-phase process: the primary mechanical injury and the subsequent cascade of auto-destructive damages. This cascade leads to inflammation, hemorrhage, demyelination, axon disruption, apoptosis, and necrosis.
Neurospine, 2024 • June 1, 2024
This study demonstrates that MSC-Exo treatment can effectively inhibit ferroptosis in BV2 cells and promote neurological recovery in SCI rats. The Nrf2/GCH1/BH4 signaling pathway plays a crucial role ...
KEY FINDING: MSC-Exo effectively inhibited the production of ferrous iron, lipid peroxidation products, and ferroptosis-promoting factor prostaglandin-endoperoxide synthase 2.
CNS Neurosci Ther, 2024 • June 18, 2024
This study aimed to confirm the inhibitory effect of nicotinamide on fibrotic scar formation following spinal cord injury (SCI) in mice using functional metabolomics. The researchers employed a novel ...
KEY FINDING: Nicotinamide (NAM) administration led to a reduction in fibrotic lesion area following spinal cord injury in mice.
Cells, 2024 • July 8, 2024
The study demonstrates that transplanting Schwann cells overexpressing GDNF into a completely transected spinal cord promotes the regeneration of propriospinal axons. GDNF improves the integration of ...
KEY FINDING: GDNF significantly improved graft-host integration by promoting the migration of reactive astrocytes into the Schwann cell territory.
Biological Research, 2024 • August 5, 2024
The in situ overexpression of NeuroD1 and Ngn2 in the spinal cord after spinal cord injury can reprogram astrocytes into neurons and significantly enhance cell regeneration at the injury site. The rep...
KEY FINDING: Overexpression of NeuroD1 and Ngn2 in astrocytes promotes cell regeneration at the injury site after spinal cord injury.
Scientific Reports, 2024 • August 2, 2024
This study investigated the effects of repetitive magnetic stimulation (rMS) on neuronal death and nerve regeneration following peripheral nerve injury (PNI) in rats. The results indicated that rMS ca...
KEY FINDING: rMS prevents the decrease in DRG neurons post-injury, showing significantly higher DRG neuron counts at 1- and 4-weeks post-injury compared to the control group.
Int. J. Mol. Sci., 2024 • August 21, 2024
This study aimed to assess the effectiveness of epidural electric stimulation in promoting motor recovery in rats with spinal cord injury, as well as to elucidate the neurophysiological mechanisms und...
KEY FINDING: Epidural electrical stimulation (eSCS) significantly improved motor function in rats with spinal cord injury, as measured by the BBB scale.
Advanced Healthcare Materials, 2024 • September 1, 2024
This study introduces a biohybrid nerve graft made of decellularized rat sciatic nerve and PEDOT, optimized for electrical conductivity, mechanical properties, and biocompatibility. The optimized bioh...
KEY FINDING: A biohybrid nerve with a 1:1 ratio of FeCl3 to EDOT, cycled twice (DNP1:1C2), exhibited superior conductivity, mechanical alignment, and biocompatibility.
Cureus, 2024 • September 5, 2024
This case series investigated the use of autologous platelet-rich fibrin (PRF) on chronic non-healing ulcers with various etiologies in a rehabilitation center. The results indicate that PRF is a safe...
KEY FINDING: PRF treatment led to a maximum healing rate of 3.84% per day based on the PUSH score.