Transcriptome profile analysis in spinal cord injury rats with transplantation of menstrual blood-derived stem cells

This research explores how menstrual blood-derived stem cells (MenSCs) can help in treating spinal cord injury (SCI) in rats. By looking at the expression patterns of RNAs, the study aims to understand the molecular mechanisms behind MenSCs' therapeutic effects. The study involved transplanting MenSCs into the injured spinal cords of rats and then analyzing the changes in gene expression using RNA sequencing. This helps identify which genes and pathways are affected by the MenSCs treatment. The findings reveal that MenSCs treatment leads to significant changes in the expression of various RNAs, including lncRNAs, circRNAs, miRNAs, and mRNAs, which are involved in the recovery of injured rats through pathways like cell adhesion and immune response.

• 1
  MenSCs treatment improves motor function recovery and reduces spinal cord lesion volume in SCI rats.
• 2
  Significant changes in the expression of lncRNAs, circRNAs, miRNAs, and mRNAs were observed in MenSCs-treated rats compared to SCI rats.
• 3
  Key pathways involved in SCI regeneration include cell adhesion molecules, natural killer cell-mediated cytotoxicity, and chemokine signaling pathways.