Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 531-540 of 2,298 results
Not specified, 2023 • July 19, 2023
This study demonstrates that a combination of acute PLG bridge implantation and chronic hNSC transplantation enhances neurorepair after spinal cord injury (SCI). The PLG bridge provides a permissive e...
KEY FINDING: PLG bridge implantation modulates the cellular immune response in vivo by prolonging the macrophage/microglial response.
Journal of Translational Medicine, 2023 • July 20, 2023
This study comprehensively maps transcriptional changes in young and old DRGs after injury, identifying hub genes and related drugs affecting axon regeneration. The research pioneers the construction ...
KEY FINDING: Identified 693 and 885 DEGs in old and young mice, respectively, after peripheral nerve injury, with shared DEGs involved in inflammatory and immune responses.
Medicina, 2023 • July 1, 2023
Cell transplantation therapy using hiPSC-NS/PCs has shown promise for SCI treatment, particularly in the subacute phase. However, chronic SCI presents challenges due to scarring and other factors. The...
KEY FINDING: Cell transplantation therapy is more effective in the subacute phase of SCI than in the chronic phase.
JOURNAL of MEDICINE and LIFE, 2023 • April 1, 2023
The study aimed to compare the differentiation and survival of human neural stem/progenitor cells of various origins in vitro and after transplantation into the injured spinal cord of laboratory anima...
KEY FINDING: HUES6 and iPSC neurospheres displayed markers associated with glial differentiation.
Stem Cells Translational Medicine, 2023 • August 24, 2023
In the current study, we presented novel findings suggesting that hiPSC-oNPCs are a promising cell source for cervical SCI treatment. We observed that these cells predominantly differentiated into oli...
KEY FINDING: Following transplantation, the oNPCs engrafted, migrated to the rostral and caudal regions of the lesion, and demonstrated preferential differentiation toward oligodendrocytes.
Regenerative Therapy, 2023 • March 31, 2023
This study demonstrates that Tanshinone IIA (TSIIA) protects motor neuron-like NSC-34 cells from lipopolysaccharide (LPS)-induced cell injury. The protective effect of TSIIA is mediated by the regulat...
KEY FINDING: TSIIA alleviates cell injury induced by LPS and increases TCTN2 expression in LPS-exposed NSC-34 cells.
Regenerative Therapy, 2023 • September 4, 2023
This study investigates the combined effects of human placental mesenchymal stem cell-derived exosomes (hpMSCs-Exos) and hyperbaric oxygen (HBO) on spinal cord ischemia-reperfusion injury (IR) in rats...
KEY FINDING: The combination of hpMSCs-Exos and HBO significantly increased neuronal survival and decreased gliosis (proliferation of glial cells) in the spinal cord.
Frontiers in Pharmacology, 2023 • September 20, 2023
The study uses a systems pharmacology approach to identify a four-drug combination (IL-6, HU-210, Taxol, and APC) that promotes axonal regeneration after injury in the rat optic nerve crush model. The...
KEY FINDING: The combination of IL-6 and HU-210 stimulates neurite outgrowth in an inhibitory environment by promoting neuroprotection and enabling neurite outgrowth.
iScience, 2023 • November 17, 2023
This study demonstrated the long-term fate and safety of human ESC-derived dorsal spinal dI4/dILA NPCs in adult naive rat spinal cords over 1 year. The majority of differentiated human neurons were PT...
KEY FINDING: Human spinal GABA neurons survived long-term and fully matured in the rat spinal cord after transplantation, differentiating into neurons and astrocytes.
Basic and Clinical Neuroscience, 2023 • July 1, 2023
This study summarizes the efficacy of MSC-EVs, including exosomes, alone or in combination with scaffolds in the treatment of SCI and then discusses the therapeutic outcomes observed in SCI experiment...
KEY FINDING: MSC-EVs, including exosomes, alone or in combination with scaffolds can can regenerate the injured nerve in SCI.