Transplantation of fibrin-thrombin encapsulated human induced neural stem cells promotes functional recovery of spinal cord injury rats through modulation of the microenvironment

This study explores using transplanted cells and biomaterials to improve the environment around a spinal cord injury. Human cells, similar to stem cells, were combined with a blood clotting material and placed at the injury site in rats. The treatment helped the rats regain movement and nerve function, reduced tissue damage, and supported nerve fiber growth at the injury location.

• 1
  Transplanted iNSCs survived for a short period but induced long-lasting changes in the microenvironment.
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  iNSC transplantation reduced the number of infiltrated immune cells and shifted microglia towards a regenerative phenotype.
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  iNSC transplantation reduced lesion volume and improved axon myelination.