Regenerative Medicine Research

KEY FINDING: Gene therapies show an overall improvement in locomotor scores in preclinical models of spinal cord injury.

KEY FINDING: CFA-induced inflammatory pain in rats leads to ferroptosis in the spinal cord and dorsal root ganglion tissues.

KEY FINDING: BM-PACs can secrete HGF in response to pro-inflammatory cytokines, such as TNF-α and IL-1β, and exhibit migration ability toward these cytokines.

KEY FINDING: The review highlights the potential of using human-induced pluripotent stem cells (hiPSCs) to generate spinal motor neurons from neuromesodermal progenitors (NMPs) for SCI therapy.

KEY FINDING: High-dose (≥ 1 × 106) transplantation of UCMSCs showed a significantly better therapeutic effect compared to low-dose (< 1 × 106) transplantation.

KEY FINDING: Stem cell therapy improved the ASIA impairment scale score by at least one grade in 48.9% of patients with spinal cord injury, indicating a slight improvement in sensory and motor function.

KEY FINDING: MiR-31 promotes the proliferation of BMSCs in vitro, as demonstrated by CCK-8 and Cell-cycle assays.

KEY FINDING: A single intrathecal injection of sEVs durably reversed mechanical hypersensitivity in the left hind paw of mice with partial sciatic nerve ligation.

KEY FINDING: IGF-1 enhances the proliferation and survivability of BMSCs-derived neural progenitor cells (NPCs) by downregulating miR-22-3p.

KEY FINDING: The biological sex of donor cells does not significantly influence graft neuron density, glial differentiation, formation of the reactive glial cell border, or graft axon outgrowth.