Regenerative Medicine Research

KEY FINDING: NABDM modifies the polarization direction of microglia in vitro, and promotes the differentiation of NSCs by activating the cGMP–PKG and cAMP signaling pathways.

KEY FINDING: MSC-derived CM contains growth factors and cytokines that protect nerve cells. These include stem cell factor (SCF), vascular endothelial growth factor (VEGF), and glial cell line-derived neurotrophic factor (GDNF).

KEY FINDING: Promising results have been reported for patients with subacute SCI, especially in studies involving MSCs, such as those conducted with Stemirac, although no universally recognized breakthroughs have been achieved.

KEY FINDING: Immature CiN cell transplantation partially improves spontaneous motor activity in marmoset models of SCI.

KEY FINDING: STS significantly reduced the levels of inflammatory indices in the LPS-induced rats NSCs inflammation model and improved the viability of rats NSCs following inflammatory injury.

KEY FINDING: CSF-cNs, isolated using a Pkd2l1 promoter-driven GFP reporter, exhibit excellent self-renewal capability in vitro.

KEY FINDING: Adipose-derived stem cells (ASC) promote pressure ulcer healing by promoting adipogenic differentiation and regeneration of the skin's architecture in both young and old mice.

KEY FINDING: There were no significant differences in ulcer healing between conventional surgery and cell therapy in the first 6 months.

KEY FINDING: Mesenchymal stem cells (MSCs) have the capacity for self-renewal and can differentiate into any type of cell and exhibit immunomodulatory, anti-inflammatory, and tissue repair properties.

KEY FINDING: Differentially expressed genes (DEGs) were identified between the rostral and caudal regions at different time points following SCI, including Col3a1, Col1a1, Dcn, Fn1, Kcnk3, and Nrg1.