Intrathecal liproxstatin-1 delivery inhibits ferroptosis and attenuates mechanical and thermal hypersensitivities in rats with complete Freund’s adjuvant-induced inflammatory pain

This study investigates the role of ferroptosis, a type of cell death, in inflammatory pain. The research focuses on the spinal cord and dorsal root ganglion (DRG) tissues of rats with complete Freund’s adjuvant (CFA)-induced inflammatory pain. The study found that ferroptosis occurs in the spinal cord and DRG tissues of these rats, contributing to pain. Blocking ferroptosis with a drug called liproxstatin-1 reduced pain symptoms. The findings suggest that targeting ferroptosis in the spinal cord and DRG could be a potential new way to treat inflammatory pain. Intrathecal delivery of liproxstatin-1 shows promise as a therapeutic strategy.

• 1
  CFA-induced inflammatory pain in rats leads to ferroptosis in the spinal cord and dorsal root ganglion tissues.
• 2
  Intrathecal administration of liproxstatin-1, a ferroptosis inhibitor, alleviates mechanical and thermal hypersensitivities in CFA-treated rats.
• 3
  Ferroptosis-related changes, including iron overload, lipid peroxidation, and dysregulation of ACSL4 and GPX4, are reversed by liproxstatin-1 treatment.