Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 371-380 of 2,298 results
Frontiers in Cellular Neuroscience, 2022 • August 29, 2022
This study investigates the therapeutic effects of human umbilical cord mesenchymal stem cell-derived small extracellular vesicles (hucMSC-sEVs) on spinal cord injury (SCI) in a rat model. The finding...
KEY FINDING: hucMSC-sEVs dramatically promoted the recovery of spinal cord function in a rat model of SCI, as evidenced by improved BBB scores.
Genes, 2022 • September 16, 2022
This study investigates the molecular basis of adipose-derived stem cell (ASC) differentiation into chondrocytes, using canine material, to serve as a transcriptomic reference for further research aim...
KEY FINDING: Several genes (e.g., MMP12, MPEG1, CHI3L1, and CD36) were identified as potential new markers of chondrogenesis. These genes could indicate how culture conditions affect ASCs.
International Journal of Biological Sciences, 2022 • August 29, 2022
This study demonstrates the therapeutic potential of VitD after TSCI by improving the integrity of myelin sheath through c-Myc suppression. Although the mechanisms of injury and pathophysiological alt...
KEY FINDING: VitD treatment post-TSCI effectively improved hindlimb movement in rats with normal VitD level irrespective of injury severity.
Nature Communications, 2022 • October 3, 2022
This study investigates the influence of lesion environments on the fate of transplanted neural progenitor cells (NPCs) in mice. NPCs were transplanted into either uninjured CNS or subacute CNS lesion...
KEY FINDING: NPCs transplanted into uninjured CNS differentiate into cells transcriptionally similar to healthy astrocytes and oligodendrocytes.
Neurospine, 2022 • September 1, 2022
This review summarizes current research findings about the role of MSCs in improving complex pathology after SCI. MSCs exert a multimodal repair mechanism targeting multiple events in the secondary in...
KEY FINDING: MSCs can promote angiogenesis and vasculogenesis when transplanted into tissues, which is critical for tissue regeneration after SCI.
Inflammation and Regeneration, 2022 • September 1, 2022
This study explored the therapeutic potential of platelet-rich plasma (PRP) for treating multiple sclerosis (MS) in cats, utilizing an ethidium bromide (EB)-induced demyelination model. The research a...
KEY FINDING: PRP had a significant positive effect on motor function of the hindlimbs, with improvements observed as early as day 20.
Bioengineering, 2022 • October 9, 2022
The study investigates the therapeutic potential of human amniotic epithelial cell (hAEC)-derived neural-like cells delivered via a 3D-printed biomimetic scaffold for spinal cord injury (SCI) treatmen...
KEY FINDING: Human amniotic epithelial cells (hAECs) can be effectively induced into neural-like cells using a compound cocktail (BGVB), showing morphological changes and expression of neural cell markers.
Int. J. Mol. Sci., 2022 • September 28, 2022
This review provides a quantitative analysis of 492 clinical trials focusing on stem cells in neurologic disorders, identifying trends in stem cell origins, indications, and trial phases. The most com...
KEY FINDING: Mesenchymal stem cells (MSCs) are the most common type of stem cell used, accounting for 83% of clinical trials.
Neural Regeneration Research, 2023 • October 10, 2022
This review summarizes the regulatory role of Chx10-expressing V2a spinal interneurons in spinal locomotion and spinal cord disease, noting their origin in the p2 progenitor domain and induction by No...
KEY FINDING: Chx10+V2a interneurons originate from the p2 progenitor domain and are directed by Notch and TGF-β signals, which suppress motoneuron fates, ensuring the appropriate balance of V2a/V2b commitment through transcription factors.
Ann Transl Med, 2022 • September 1, 2022
This study used iTRAQ proteomics to analyze the proteome profiles of BMSCs cocultured with SCs, identifying 243 differentially expressed proteins (DEPs). Bioinformatics analyses (GO and KEGG) indicate...
KEY FINDING: A total of 6,760 types of proteins were detected, with 5,181 having quantitative information. Among these, 243 DEPs were identified.