Regenerative Medicine Research

KEY FINDING: The combination of ceftriaxone and ADMSCs resulted in significantly lower levels of TNF-α and IL-6 in both circulatory and spinal cord fluid compared to ceftriaxone or ADMSCs alone, indicating a stronger anti-inflammatory effect.

KEY FINDING: CP patients showed improved motor and cognitive function with reduced GMFCS scores (p<0.001).

KEY FINDING: Significant reductions were observed in pain interference with daily activities, mood, and sleep in the treatment group compared to the control group after 6 months.

KEY FINDING: CTGF was found to be the most effective growth factor for inducing the differentiation of UCMSCs into tendon cells, leading to changes in cell morphology and increased expression of tendon-specific proteins.

KEY FINDING: hUCMSC transplantation improved motor function in rats with SCI, particularly on days 7 and 14 post-injury, as measured by the BBB locomotor rating scale and Rivlin inclined plane test.

KEY FINDING: Umbilical cord blood-derived mononuclear cells-treated groups exhibited significant reductions in necrosis, hemorrhage, and degeneration compared to controls.

KEY FINDING: MSC-exos significantly improved hind limb movement in SCI-affected rats, as indicated by a statistically significant increase in BBB scores compared to controls.

KEY FINDING: Parthenogenetic stem cells can differentiate into various cell types, including neural stem cells, mesenchymal stem cells, and cardiomyocytes, suggesting their broad therapeutic potential for regenerative medicine.

KEY FINDING: X-SCID rats exhibited significantly higher retention of transplanted NPCs compared to both Wistar and RNU rats, indicating that both T and B cells play crucial roles in the rejection of xenografted human NPCs.

KEY FINDING: MSC-Exos have low immunogenicity, are more accessible, have improved preservation qualities, and potentially have low carcinogenic risks compared to MSCs.