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  4. Treatment of pressure ulcers in patients with spinal cord injury: Conventional surgery vs. cellular therapy

Treatment of pressure ulcers in patients with spinal cord injury: Conventional surgery vs. cellular therapy

The Journal of Spinal Cord Medicine, 2024 · DOI: 10.1080/10790268.2021.2014234 · Published: January 1, 2024

Spinal Cord InjuryRegenerative MedicineDermatology

Simple Explanation

This study compares conventional surgery with cellular therapy (infusion of bone marrow mononuclear cells) for treating pressure injuries (PIs) in patients with spinal cord injuries. The study found that while cellular therapy showed promise initially, conventional surgery proved more effective in the medium to long term for PI treatment. The research suggests that bone marrow mononuclear cell infusion-infiltration could be an alternative treatment for PIs during the first 6 months, but conventional surgery is more effective later on.

Study Duration
14-year follow-up period
Participants
149 patients with spinal cord injuries and pressure injuries
Evidence Level
Retrospective study

Key Findings

  • 1
    There were no significant differences in ulcer healing between conventional surgery and cell therapy in the first 6 months.
  • 2
    At 6 months and one-year post-treatment, conventional surgery showed significantly better outcomes than cell therapy.
  • 3
    A statistically significant relationship was found between days of hospitalization and the type of bacterial contamination and the intervention group.

Research Summary

The study compared conventional surgery and bone marrow mononuclear cell infusion-infiltration for treating pressure injuries (PIs) in spinal cord injured patients over a 14-year period. Initial results showed no significant difference between the two treatments in the first 6 months, but conventional surgery demonstrated better long-term outcomes. The research suggests that while cell therapy may offer short-term benefits, conventional surgery is more effective for PIs in the medium to long term.

Practical Implications

Treatment Choice

Consider conventional surgery as the primary treatment for pressure injuries in spinal cord injury patients due to its long-term effectiveness.

Alternative Therapy

Bone marrow mononuclear cell infusion-infiltration may be considered as an alternative for short-term treatment (first 6 months) of PIs.

Hospital Stay

Cell therapy may contribute to faster recovery, potentially resulting in a shorter hospital stay, particularly in the initial postoperative months.

Study Limitations

  • 1
    Retrospective study design
  • 2
    Single-center study
  • 3
    Lack of data on long-term effects of cell therapy beyond one year

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