Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 261-270 of 2,298 results
Neural Regeneration Research, 2014 • June 1, 2014
This study examined the effects of miRNA-124 (miR-124) overexpression in bone marrow-derived mesenchymal stem cells, focusing on their differentiation into neurons. The researchers found that miR-124 ...
KEY FINDING: miR-124 expression is substantially reduced in bone marrow-derived mesenchymal stem cells compared with neural stem cells and neurons.
Neural Regen Res, 2014 • February 1, 2014
This review discusses the extracellular matrix (ECM) and its role in axonal outgrowth regulation following central nervous system (CNS) injury, focusing on proteoglycan structure and function. It high...
KEY FINDING: Specific receptors for CSPGs have been identified, suggesting that CSPGs inhibit axon growth through multiple mechanisms, opening new avenues for therapeutic development.
Neural Regen Res, 2014 • February 1, 2014
Proteoglycans (PGs) in the central nervous system play integral roles as “traffic signals” for the direction of neurite outgrowth. The review further describes the methods routinely used to determine ...
KEY FINDING: Proteoglycans (PGs) in the central nervous system play integral roles as “traffic signals” for the direction of neurite outgrowth, influencing regeneration after injury.
Neural Regeneration Research, 2014 • March 1, 2014
The limited axonal growth after central nervous system (CNS) injury such as spinal cord injury presents a major challenge in promoting repair and recovery. Here, we argue that sprouting of uninjured a...
KEY FINDING: Inhibition of Nogo signaling leads to axon sprouting after spinal cord injury. Administration of an antibody that recognizes Nogo-A increased sprouting of the intact CST and functional recovery.
Neural Regen Res, 2014 • March 1, 2014
The field of spinal cord injury research has evolved, with some trends losing momentum and new approaches emerging. A balanced treatment approach for spinal cord injury is needed, including neuroprote...
KEY FINDING: Treatments aimed at promoting regeneration have been found to promote sprouting of spared and injured nerve cells, further supporting the shift towards studying neuroplasticity.
Neural Regeneration Research, 2014 • February 1, 2014
Axon growth is crucial for nervous system development and post-injury recovery. CSPGs and HSPGs, acting like traffic signals, respectively inhibit and promote axon growth. The identification of LAR an...
KEY FINDING: CSPGs and HSPGs have opposite effects on axonal behavior, with CSPGs often acting as repulsive guidance molecules and HSPGs as attractive signals.
Neural Regeneration Research, 2014 • March 1, 2014
This novel technology has opened new therapeutic opportunities to generate stem cells in any tissue for cell replacement therapy in a number of disorders. Cell reprogramming technology provides a nove...
KEY FINDING: Somatic mammalian cells can be epigenetically reprogrammed to induced pluripotent stem cells (iPSCs) through the exogenous expression of the Oct4, Sox2, Klf4 and c-Myc (OSKM).
Neural Regeneration Research, 2014 • March 1, 2014
This study investigated the effects of puerarin on neural regeneration after sciatic nerve injury in mice. Puerarin was administered at different doses, and its impact on GAP43 expression, muscle atro...
KEY FINDING: Puerarin at middle and high doses significantly up-regulated the expression of growth-associated protein 43 in the L4–6 segments of the spinal cord from mice at 1, 2, and 4 weeks after modeling.
Neural Regeneration Research, 2014 • April 1, 2014
This study aimed to determine if RNA interference to silence the Nogo-66 receptor gene in bone marrow mesenchymal stem cells before transplantation could improve neurological function in rats with spi...
KEY FINDING: The number of neurons and BrdU-positive cells was significantly higher in the Nogo-66 receptor gene silencing group compared to the bone marrow mesenchymal stem cell and model groups.
Neurobiol Dis, 2015 • January 1, 2015
In this study, we demonstrate that transgenic deletion of LAR increased growth of descending serotonergic axons and CST fibers in reactive scar tissues and caudal spinal cord after SCI. Furthermore, L...
KEY FINDING: LAR deletion increased regrowth of serotonergic axons into scar tissues and caudal spinal cord after dorsal overhemitransection.