Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 271-280 of 2,298 results
Neural Regeneration Research, 2014 • July 1, 2014
Myelin regeneration is critical for treating CNS disorders like MS and SCI, as it restores neurophysiology and protects axons from degeneration. Understanding the mechanisms of remyelination is essent...
KEY FINDING: Myelin regeneration shares similarities with myelin development, involving OPC proliferation, migration, differentiation, and myelination, but remyelinated axons often have thinner myelin sheaths and different nodal domain cytoarchitecture.
Stem Cell Reports, 2014 • August 7, 2014
This study compares TALENs and CRISPRs for gene knockout in axolotls, finding CRISPRs to be more efficient and less toxic. Deletion of Sox2, a key neural stem cell gene, was achieved using CRISPR tech...
KEY FINDING: CRISPRs are more effective and less toxic than TALENs for gene knockout in axolotls, achieving higher knockout penetrance.
Exp Neurobiol, 2014 • September 1, 2014
The review paper discusses recent accomplishments in cell transplant treatment for ALS and future options with iPSC technology. The paper highlights the potential of cell-based therapies, including MS...
KEY FINDING: Mesenchymal stem cell (MSC) transplantation has shown minor improvements in ALS patients, with some studies suggesting that pre-selecting MSCs based on biomarkers could optimize treatment outcomes.
Journal of Cancer, 2014 • September 20, 2014
This review discusses the role of fibroblasts in salamander limb regeneration and contrasts their activity with that of human fibroblasts in wound healing and cancer. It examines how the salamander's ...
KEY FINDING: Salamander regeneration can reverse tumorigenicity, as demonstrated by the reversion of frog tumor cells to normal tissues in regenerating limbs.
BioMed Research International, 2014 • September 18, 2014
Following any insult to the CNS, traumatic or degenerative, an inflammatory reaction occurs, and the activation of microglia, astrocytes, and invasion of vascular macrophages result in an upregulation...
KEY FINDING: CSPGs are upregulated rapidly in the tissue surrounding a lesion site, due to the induction of reactive gliosis.
Neural Regen Res, 2012 • December 1, 2012
This study performed a bibliometric analysis of studies on transplantation of neural stem cells, Schwann cells and olfactory ensheathing cells for spinal cord injury published from 2002 to 2011 retrie...
KEY FINDING: The number of publications on neural stem cells, Schwann cells, and olfactory ensheathing cells for spinal cord injury increased over the 10-year period.
Neural Regen Res, 2012 • December 1, 2012
This study investigated the influence of Tanshinone IIa on apoptosis-related protein HSP70, Bcl-2 and Bax expression in spinal nerve cell apoptosis after ischemia/ reperfusion injury. Tanshinone IIa m...
KEY FINDING: Tanshinone IIa promotes heat shock protein 70 and Bcl-2 protein expression in the injured spinal cord after ischemia/reperfusion injury.
Neural Regen Res, 2012 • December 1, 2012
This study examined the co-culture of human embryonic olfactory ensheathing cells, human Schwann cells, human amniotic epithelial cells and human vascular endothelial cells in complete culture medium-...
KEY FINDING: The number of all cell types in the co-culture reached a peak at 7–10 days, and the expression of nerve growth factor, brain-derived neurotrophic factor, and glial cell line-derived neurotrophic factor peaked at 9 days.
Neural Regeneration Research, 2014 • August 1, 2014
KLFs regulate intrinsic axon growth ability in central nervous system (CNS) neurons including retinal ganglion cells, and hippocampal and cortical neurons. Characterizing the molecular mechanisms of t...
KEY FINDING: KLF4 expression significantly decreased neurite outgrowth in hippocampal and cortical neurons, and RGCs.
Neural Regeneration Research, 2014 • August 1, 2014
Bone marrow mesenchymal stem cell transplantation has been shown to be therapeutic in the repair of spinal cord injury. Neurotrophin-3 promotes motor neuron survival and it is hypothesized that its tr...
KEY FINDING: NT-3 transfection increased the number of BMSCs transplanted into injured spinal cord.