Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 251-260 of 2,298 results
Neural Regen Res, 2013 • December 1, 2013
Approximately 50–70% of patients experience incision-induced mechanical nociception after surgery. However, the mechanism underlying incision-induced mechanical nociception is still unclear. Von Frey ...
KEY FINDING: Incision surgery decreased the withdrawal threshold of rats at 0.5, 3, 6 and 24 hours after incision, compared with the sham surgery group.
Neural Regen Res, 2013 • December 1, 2013
This study evaluated the effects of transplantation of hair follicle stem cells in rats with a compression-induced spinal cord lesion. Some of the grafted cells could survive and differentiate into ol...
KEY FINDING: Hair follicle stem cells can survive for a long time period in vivo and differentiate into neuronal- and glial-like cells.
Neural Regen Res, 2013 • December 1, 2013
This study investigates the feasibility of using neuronal-like cells from rabbit bone marrow mesenchymal stem cells to treat spinal cord injury, using magnetic resonance to track transplanted cells in...
KEY FINDING: Bone marrow mesenchymal stem cells can be induced to differentiate into neuronal-like cells expressing neuronal markers.
Neural Regen Res, 2013 • February 1, 2013
This study investigates the optimal time for neural progenitor cell transplantation via the subarachnoid space in rats with spinal cord injury. Cells were transplanted at acute, subacute, and chronic ...
KEY FINDING: Neural progenitor cells transplanted via the subarachnoid space can survive and improve neurological function in rats with spinal cord injuries.
Neural Regen Res, 2013 • February 1, 2013
This study investigates the impact of methylprednisolone on Nogo-A expression in rats with acute spinal cord injuries induced by the weight-drop method. The findings reveal that spinal cord injury ele...
KEY FINDING: Spinal cord injury in rats led to reduced motor behavior ability and necrotic injury in spinal cord tissues, accompanied by increased Nogo-A expression.
Neural Regeneration Research, 2013 • February 1, 2013
This study investigates the mechanism of Erhuang capsule, a traditional Chinese medicine formula, in treating multiple sclerosis using an experimental autoimmune encephalomyelitis (EAE) mouse model. T...
KEY FINDING: Erhuang capsule reduced mortality and promoted recovery of neurological functions in mice with experimental autoimmune encephalomyelitis.
Neural Regeneration Research, 2013 • March 1, 2013
This study investigated the therapeutic potential of transplanting Nogo-66 receptor gene-silenced bone marrow mesenchymal stem cells and Schwann cells, combined with a poly(D,L-lactide-co-glycolic aci...
KEY FINDING: Transplantation of Nogo-66 receptor gene-silenced cells with the scaffold significantly enhanced axonal regeneration of spinal cord neurons in rats with spinal cord injury.
Neural Regeneration Research, 2014 • May 1, 2014
This study evaluated the combined effects of glial cell line-derived neurotrophic factor transplantation combined with adipose-derived stem cells-transdifferentiated motoneuron delivery on spinal cord...
KEY FINDING: The combined therapy of motoneuron-like cell transplantation and GDNF delivery reduced cavity formation in the injured spinal cord.
Neural Regeneration Research, 2014 • May 1, 2014
This study designed and tested a novel double-layer collagen membrane with unequal pore sizes for spinal cord injury repair. The transplantation of neural stem cells in the membrane promoted cell diff...
KEY FINDING: The double-layer collagen membrane promoted the differentiation of neural stem cells in rats with spinal cord injuries.
Neural Regeneration Research, 2014 • June 1, 2014
Neuronal relays represent an essential mechanism for spinal cord injury (SCI) repair, offering an alternative or complementary approach to axon regeneration. Host interneuronal relays can facilitate r...
KEY FINDING: Locomotor recovery after spinal cord injury can be mediated by remodeling of bulbospinal and propriospinal connections, where new propriospinal relay circuits bypass the lesion site.