Role of CSPG receptor LAR phosphatase in restricting axon regeneration after CNS injury

Extracellular matrix molecule chondroitin sulfate proteoglycans (CSPGs) are highly upregulated in scar tissues and form a potent chemical barrier for CNS axon regeneration. The receptor protein tyrosine phosphatase σ (PTPσ) and its subfamily member leukocyte common antigen related phosphatase (LAR) act as transmembrane receptors to mediate CSPG inhibition. LAR deletion increased regrowth of serotonergic axons into scar tissues and caudal spinal cord after dorsal overhemitransection. LAR deletion also stimulated regrowth of CST fibers into the caudal spinal cord.

• 1
  LAR deletion increased regrowth of serotonergic axons into scar tissues and caudal spinal cord after dorsal overhemitransection.
• 2
  LAR deletion also stimulated regrowth of CST fibers into the caudal spinal cord.
• 3
  LAR deletion improved functional recovery by increasing BMS locomotor scores and stride length and reducing grid walk errors.