Bone marrow mesenchymal stem cells with Nogo-66 receptor gene silencing for repair of spinal cord injury

This study investigates the use of bone marrow mesenchymal stem cells (BMSCs) with silenced Nogo-66 receptor genes to repair spinal cord injuries in rats. The researchers hypothesized that silencing the Nogo-66 receptor gene in BMSCs before transplantation would improve neurological function in rats with spinal cord injury. The study found that transplantation of Nogo-66 receptor-silenced BMSCs improved nerve fiber growth, tissue ultrastructure, and behavioral performance in rats with spinal cord injury.

• 1
  The number of neurons and BrdU-positive cells was significantly higher in the Nogo-66 receptor gene silencing group compared to the bone marrow mesenchymal stem cell and model groups.
• 2
  Behavioral performance was significantly enhanced in the Nogo-66 receptor gene silencing group.
• 3
  The number of horseradish peroxidase-labeled nerve fibers was higher in the Nogo-66 receptor gene silencing group than in the bone marrow mesenchymal stem cell group, and significantly higher than in the model group.