Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 231-240 of 2,298 results
Biomaterials, 2014 • October 1, 2014
The study investigates the potential of thrombin inhibitors to improve cellular regeneration after spinal cord injury. PLGA microspheres and Pluronic F-127 hydrogels were used to create depot formulat...
KEY FINDING: Thrombin increases endogenous neural progenitor proliferation in the intact murine spinal cord.
Neuron, 2014 • August 20, 2014
Human iPSC-derived neural stem cells were grafted into sites of rat spinal cord injury and were found to extend axons over virtually the entire length of the rat central nervous system. These human ax...
KEY FINDING: Human iPSC-derived NSCs survived and differentiated into neurons and glia after transplantation into rats with spinal cord injuries.
PLoS ONE, 2014 • August 26, 2014
The study compared local injection of mononuclear cells (MC) to the spinal cord lateral funiculus with local delivery with fibrin sealant after ventral root avulsion (VRA) and reimplantation. Cell the...
KEY FINDING: Mononuclear cell therapy resulted in greater survival of spinal motoneurons up to four weeks post-surgery, especially when mononuclear cells were added to the fibrin glue.
PLoS ONE, 2014 • September 2, 2014
The study examined the effectiveness of electrical stimulation (ES) on nerve regeneration after delayed nerve repair in rats, with delays ranging from one day to two months. The results indicated that...
KEY FINDING: Electrical stimulation promotes nerve regeneration after delayed repair, but the effective interval is less than 1 month.
Asian Spine J, 2014 • August 1, 2014
The study investigates the safety and feasibility of cotransplantation of bone marrow stem cells and autologous olfactory mucosa in chronic spinal cord injury patients with AIS A neurological impairme...
KEY FINDING: The cotransplantation procedure was found to be safe and feasible for patients with thoracic level injuries, as assessed at the 24-month follow-up.
Cell Transplant, 2015 • September 1, 2015
This study investigates the safety and efficacy of autologous adherent bone marrow cell (ABMC) therapy in a canine model of spinal cord injury (SCI). The results demonstrate that intrathecal transplan...
KEY FINDING: GFP-labeled ABMCs were found in the injured spinal cord for up to 16 weeks after transplantation.
Neural Regen Res, 2013 • January 1, 2013
The study investigated the distribution of GABA, tyrosine hydroxylase, and nitric oxide-producing elements in the brain of cherry salmon at different life stages using immunohistochemical and histoche...
KEY FINDING: Distribution features of nitric oxide and classical neuromediators γ-aminobutyric acid and catecholamines are closely associated with the ability of the fish brain to grow during the entire lifespan.
Neural Regeneration Research, 2013 • April 1, 2013
This study investigates the potential of human umbilical mesenchymal stem cell-derived oligodendrocyte precursor cells (HUMSC-OPCs) to promote axon and myelin sheath regeneration in a rat model of spi...
KEY FINDING: Human umbilical mesenchymal stem cells can be induced to differentiate into oligodendrocyte precursor-like cells in vitro using neurobasal medium and nerve growth factors.
Neural Regen Res, 2013 • April 1, 2013
This study investigated the combined effects of chondroitinase ABC and bone marrow mesenchymal stem cell transplantation on spinal cord injury repair in rats. The combination therapy resulted in impro...
KEY FINDING: The combination group showed significantly higher Basso, Beattie and Bresnahan scores at 14 days after spinal cord injury, indicating improved motor function compared to other groups.
Neural Regen Res, 2013 • May 1, 2013
This bibliometric analysis examines the trends and characteristics of research on olfactory ensheathing cell (OEC) transplantation for spinal cord injury (SCI) over an 18-year period. The study identi...
KEY FINDING: The number of publications on OEC transplantation for SCI has shown an increasing trend over the past decade.