Influence of Delivery Method on Neuroprotection by Bone Marrow Mononuclear Cell Therapy following Ventral Root Reimplantation with Fibrin Sealant

This study investigates the effectiveness of using mononuclear cells (MC) from bone marrow to protect nerve cells after a ventral root avulsion (VRA), a type of nerve injury, in rats. The researchers compared two methods of delivering these cells: injecting them directly into the spinal cord and mixing them with a fibrin sealant to help repair the damaged nerve roots. The study found that both methods of cell therapy helped to protect the nerve cells, but using the fibrin sealant to deliver the MCs resulted in better and longer-lasting protection. This method also increased the levels of certain growth factors that help nerve cells survive and function. These findings suggest that using a fibrin sealant to deliver bone marrow MCs could be a promising approach for treating nerve injuries like brachial plexus lesions in humans, as it appears to provide better nerve cell protection and promote recovery.

• 1
  Mononuclear cell therapy resulted in greater survival of spinal motoneurons up to four weeks post-surgery, especially when mononuclear cells were added to the fibrin glue.
• 2
  Mononuclear cells added to the fibrin glue increased neurotrophic factor gene transcript levels in the spinal cord ventral horn.
• 3
  The use of fibrin sealant mononuclear cells delivery approach gave the best and more long lasting results.