Safety Profile, Feasibility and Early Clinical Outcome of Cotransplantation of Olfactory Mucosa and Bone Marrow Stem Cells in Chronic Spinal Cord Injury Patients

This study explores the use of tissue engineering, where biological substitutes are developed to regenerate tissues or restore biological functions, specifically for spinal cord injuries. The study involved transplanting bone marrow and olfactory mucosal stem cells into the spinal cord of patients with spinal injuries to assess the safety and early clinical results of this method. The procedure aims to leverage the regenerative properties of stem cells to potentially repair damaged spinal cords and improve neurological function in individuals with paraplegia.

• 1
  The cotransplantation procedure was found to be safe and feasible for patients with thoracic level injuries, as assessed at the 24-month follow-up.
• 2
  No significant improvement in ASIA scores was observed, indicating no demonstrable efficacy in terms of neurological recovery.
• 3
  MRI evaluations showed an increase in the length of myelomalacia in seven participants, suggesting potential adverse effects or disease progression.