Browse the latest research summaries in the field of regenerative medicine for spinal cord injury patients and caregivers.
Showing 211-220 of 2,298 results
J Orthop Sci, 2014 • May 13, 2014
This review focuses on regenerative medicine research using cells, scaffolds, and miRNA for clinical application in orthopedics. It highlights the importance of these components in tissue engineering ...
KEY FINDING: The use of cells combined with a cell-delivery system, miRNA, scaffold, and cytokines has led to effective regeneration of musculoskeletal tissues including cartilage, bone, ligaments, muscle, peripheral nerves, and spinal cord.
PLoS ONE, 2014 • May 15, 2014
This study demonstrates that human adipose-derived stromal cells (hADSCs) improve open field locomotion after spinal cord injury in rats. hADSCs secreted human laminin, accumulating in the spinal cord...
KEY FINDING: hADSCs promote complete recovery of motor function after 8 weeks, while improving tissue preservation, restricting inflammation and stimulating axonal growth.
Methods Mol Biol, 2014 • January 1, 2014
Recombinant adeno-associated viral (AAV) vectors are one of the most promising therapeutic delivery systems for gene therapy to the central nervous system (CNS). One major limitation of AAV vectors is...
KEY FINDING: The 2A peptide sequence is only 24 amino acids long and can mediate efficient bicistronic expression of two gene products from a single promoter by undergoing ribosomal skipping (referred to as "self-cleavage") during protein translation.
PNAS, 2014 • May 19, 2014
This study provides the first real-time imaging of transplanted stem cell-mediated remyelination in a mouse model of MS. Using two-photon microscopy and viral-induced demyelination, we describe a tech...
KEY FINDING: NPCs transplanted into spinal cords of JHMV-infected mice exhibited diminished migration velocities and increased proliferation compared with transplanted cells in noninfected mice.
Cell Calcium, 2014 • July 1, 2014
This study shows that muscle cell precursors in regenerating tissues exhibit spontaneous calcium transients after tail amputation. These calcium transients are mediated by ryanodine receptor-operated ...
KEY FINDING: Muscle cell precursors in regenerating tails exhibit spontaneous calcium transients.
TISSUE ENGINEERING: Part A, 2014 • August 8, 2014
This study used multichannel polymer scaffolds in a complete spinal cord transection injury model in rats to compare the effects of Schwann cells and mesenchymal stem cells (MSCs) on tissue regenerati...
KEY FINDING: Axon regeneration was significantly augmented by Schwann cell implantation, while eGFP-MSCs did not support axon growth in the transected spinal cord.
Exp Neurol, 2014 • November 1, 2014
This study investigated the long-term survival, axonal growth-promotion, and myelination potential of Schwann cells (SCs) grafted into a contused spinal cord in adult rats. The key findings revealed r...
KEY FINDING: Grafted SCs-GFP exhibited remarkable survival up to 24 weeks post-grafting in the contused spinal cord of adult rats.
BMC Neuroscience, 2014 • May 5, 2014
This study investigates the potential of boundary cap neural crest stem cells (bNCSCs) to aid sensory axon regeneration after dorsal root avulsion injury in adult rodents. bNCSCs were implanted into t...
KEY FINDING: Transplanted bNCSCs showed extensive survival and differentiation after transplantation to the avulsed DRTZ.
Neural Development, 2014 • May 22, 2014
This study investigates the transcriptome-wide response to spinal cord injury in regenerative (R-) and non-regenerative (NR-) stages of Xenopus laevis to identify mechanisms underlying successful rege...
KEY FINDING: Regenerative tadpoles showed extensive transcriptome changes at 1 day after injury, while non-regenerative froglets showed changes at 6 days after injury, indicating different kinetics in the responses.
Journal of Visualized Experiments, 2014 • May 21, 2014
This video article details a method for performing spinal cord transections on larval zebrafish to study regeneration. Unlike mammals, zebrafish exhibit robust recovery after spinal cord injury. The p...
KEY FINDING: The presented method allows for high throughput spinal cord transections in larval zebrafish with low mortality and high reproducibility.